Separation of Isomeric Metabolites and Gangliosides with High Performance (Drift Tube) Ion Mobility–Mass Spectrometry

Autor: Julia L. Kaszycki, Claire Dauly, Anas Kamleh

Publikováno v: LCGC North America. :7-12

The study of metabolites and gangliosides is increasingly important in drug discovery (1) and immunology (2). Accurate analysis of biologically relevant isomers is important because their structure affects their molecular properties. Typically, the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4799f73ca76ffc95e660fed20c5958c3
https://doi.org/10.56530/lcgc.na.jw1886w1

Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high‐resolution drift tube ion mobility and varied drift gas mixtures

Autor: Ching Wu, Anas Kamleh, Julia L. Kaszycki, Benoit Colsch, François Fenaille, Claire Dauly, Aurelio La Rotta

Publikováno v: Rapid Communications in Mass Spectrometry
Rapid Communications in Mass Spectrometry, Wiley, 2019, 33 (S2), pp.3-10. ⟨10.1002/rcm.8414⟩
Rapid Communications in Mass Spectrometry, 2019, 33 (S2), pp.3-10. ⟨10.1002/rcm.8414⟩

Rationale Atmospheric pressure drift tube ion mobility is a powerful addition to the Orbitrap mass spectrometer enabling direct separation of isomers. Apart from offering high resolving power in a compact design, it also facilitates optimization of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039601dce7528cfbc1daa99532c0b2db
https://hal.inrae.fr/hal-02973674

Ultra-high-performance liquid chromatography-high-resolution mass spectrometry based metabolomics as a strategy for beer characterization

Autor: Antonio Checa, Hector Gallart-Ayala, Santiago Hernández-Cassou, Javier Saurina, Muhammad Anas Kamleh

Publikováno v: Journal of the Institute of Brewing. 122:430-436

An ultra-high performance liquid chromatography–high resolution mass spectrometry (UHPLC-HRMS) method was applied to the analysis of beers. Chromatographic profiles were recorded in both positive and negative electrospray modes and the resulting da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abc4305bd0a6ff842fed1617039e436e
https://doi.org/10.1002/jib.340

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

Autor: Dmitry Grapov, Craig E. Wheelock, Ning Xu, Mona Ståhle, Gavin Blackburn, Stuart G. Snowden, Muhammad Anas Kamleh, David G. Watson

Publikováno v: Journal of Proteome Research

Psoriasis is an immune-mediated highly heterogeneous skin disease in which genetic as well as environmental factors play important roles. In spite of the local manifestations of the disease, psoriasis may progress to affect organs deeper than the ski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a515c71e5eb29367b8be371f6fa136c3
https://doi.org/10.1021/pr500782g

Towards a platform for the metabonomic profiling of different strains of Drosophila melanogaster using liquid chromatography-Fourier transform mass spectrometry

Autor: Muhammad Anas Kamleh, Julian A. T. Dow, David G. Watson, Liang Zheng, Yahya Hobani

Publikováno v: FEBS Journal. 276:6798-6809

A platform based on hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry was developed in order to carry out metabonomics of Drosophila melanogaster strains. The method was able to detect ∼ 230 metabolites,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc13e4d793074660fdd65ddd990415c9
https://doi.org/10.1111/j.1742-4658.2009.07397.x