Multi-omics analyses reveal multimodal Fusobacterium DNA damage perturbations in colorectal cancer

Autor: Radhika Kataria, Jelmar Quist, Sunjae Lee, Anargyros Megalios, Elinor Sawyer, Thomas Hardiman, Chang Liu, Katherine Kelly, Theo Portlock, Tamar Alon-Maimon, Jonathan Wan, Gilad Bachrach, Saeed Shoaie, Anita Grigoriadis

Fusobacterium nucleatum is an opportunistic bacterial pathogen and oncogenic microbe. Using host sequencing data to systematically investigate Fusobacterium-host interactions in colorectal cancers (CRCs), we developed and orthogonally validated a mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a441a687e6bce92ffdd3ec89ddf89b5d
https://doi.org/10.21203/rs.3.rs-1642872/v1

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

Autor: Maria Roman-Escorza, Ahmed Abdullah Ahmed, Anargyros Megalios, Lennart Mulder, Serena Nik-Zainal, Tapsi Kumar, Anita Grigoriadis, Marlous Hoogstraat, Diego Mallo, Esther Lips

Publikováno v: Nature Genetics, 54(6)

Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is whether the invasive dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6de9ea0abd290d60fa433c7dfa7f26
http://resolver.tudelft.nl/uuid:d05f0d5b-8dd1-4219-bf2a-a6936f0f6cd6

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

Autor: Esther H, Lips, Tapsi, Kumar, Anargyros, Megalios, Lindy L, Visser, Michael, Sheinman, Angelo, Fortunato, Vandna, Shah, Marlous, Hoogstraat, Emi, Sei, Diego, Mallo, Maria, Roman-Escorza, Ahmed A, Ahmed, Mingchu, Xu, Alexandra W, van den Belt-Dusebout, Wim, Brugman, Anna K, Casasent, Karen, Clements, Helen R, Davies, Liping, Fu, Anita, Grigoriadis, Timothy M, Hardman, Lorraine M, King, Marielle, Krete, Petra, Kristel, Michiel, de Maaker, Carlo C, Maley, Jeffrey R, Marks, Brian A, Menegaz, Lennart, Mulder, Frank, Nieboer, Salpie, Nowinski, Sarah, Pinder, Jelmar, Quist, Carolina, Salinas-Souza, Michael, Schaapveld, Marjanka K, Schmidt, Abeer M, Shaaban, Rana, Shami, Mathini, Sridharan, John, Zhang, Hilary, Stobart, Deborah, Collyar, Serena, Nik-Zainal, Lodewyk F A, Wessels, E Shelley, Hwang, Nicholas E, Navin, P Andrew, Futreal, Alastair M, Thompson, Jelle, Wesseling, Marja, van Oirsouw

Publikováno v: Nature genetics. 54(6)

Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is whether the invasive diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc16e12a197d033dd3fbff69d2cda77f
https://pubmed.ncbi.nlm.nih.gov/35681052

Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma in situ

Autor: Deborah Collyar, Abeer M Shaaban, Tapsi Kumar, Mingchu Xu, Angelo Fortunato, Lorraine M. King, Marlous Hoogstraat, Sarah E Pinder, Nicholas N. Navin, Wim Brugman, Andrew Futreal, Maria Roman-Escorza, Marielle Krete, Mathini Sridharan, Alastair M. Thompson, Emi Sei, Anargyros Megalios, Diego Mallo, Jelle Wesseling, Frank Nieboer, Carolina Salinas-Souza, Michael Sheinman, Hilary Stobart, Lodewyk F. A. Wessels, Rana Shami, Ahmed A. Ahmed, Esther H. Lips, Jeffrey R. Marks, Serena Nik-Zainal, Lennart Mulder, Carlo C. Maley, Helen Davies, Salpie Nowinski, Vandna Shah, John Zhang, Karen Clements, Jelmar Quist, Michael Schaapveld, E. Shelley Hwang, Petra Kristel, Elinor J. Sawyer, Anita Grigoriadis, Liping Fu, Marjanka K. Schmidt, Lindy L. Visser, Brian A. Menegaz, Michiel de Maaker, Timothy Hardman

Pure ductal carcinoma in situ (DCIS) is being diagnosed more frequently through breast screening programmes and is associated with an increased risk of developing invasive breast cancer. We assessed the clonal relatedness of 143 cases of pure DCIS an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d34124ca76de07a15115ddabc2f67e1e
https://doi.org/10.1101/2021.03.22.21253209

Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Autor: Cheryl Gillett, Vandna Shah, Michael A. Simpson, Anca Mera, Angela Clifford, Iteeka Arora, Rebecca Roylance, Christos Petridis, Sarah E Pinder, Ian Tomlinson, Anargyros Megalios, Elinor J. Sawyer, Charlotte Moss

Publikováno v: Petridis, C, Arora, I, Shah, V, Megalios, A, Moss, C, Mera, A, Clifford, A, Gillett, C, Pinder, S E, Tomlinson, I P, Roylance, R, Simpson, M A & Sawyer, E J 2019, ' Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years ', Breast Cancer Research, vol. 21, no. 1 . https://doi.org/10.1186/s13058-019-1143-y
Breast Cancer Research : BCR
Breast Cancer Research, Vol 21, Iss 1, Pp 1-10 (2019)
Petridis, C, Arora, I, Shah, V, Megalios, A, Moss, C, Mera, A, Clifford, A, Pinder, S E, Tomlinson, I, Roylance, R, Simpson, M A & Sawyer, E J 2019, ' Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years ', Breast Cancer Research, vol. 21, 58 . https://doi.org/10.1186/s13058-019-1143-y

Introduction Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal breast cancer, and approximately 20% of screen-detected tumours are pure DCIS. Most risk factors for breast cancer have similar associations with DCIS and IDC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2558b4e53a19e227de42ac7d3540de64
https://doi.org/10.1186/s13058-019-1143-y