Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

Autor: Krishna Samanta, Gary R. Mirams, Anant B. Parekh

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Mitochondrial Ca2+ homoeostasis is tightly regulated and export of Ca2+ is mediated by an Na+Ca2+ exchanger. Here authors show that in depolarised mitochondria the exchanger initially operates in reverse mode, transporting cytosolic Ca2+ into the mat

Externí odkaz: https://doaj.org/article/434eb1455b9249acb8d848b2a2c21c00

Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca(2+) Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation

Autor: Yu-Ping Lin, Erica Scappini, Carlos Landaverde, Frederick Parekh-Glitsch, Charles J. Tucker, Gary R. Mirams, Anant B. Parekh

Publikováno v: Mol Cell Biol

A-kinase anchoring protein 79 (AKAP79) is a human scaffolding protein that organizes Ca(2+)/calmodulin-dependent protein phosphatase calcineurin, calmodulin, cAMP-dependent protein kinase, protein kinase C, and the transcription factor nuclear factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79717e80995f14eb7536789084679dc
https://europepmc.org/articles/PMC9670898/

Cytosolic and intra-organellar Ca2+ oscillations: mechanisms and function

Autor: Pulak Kar, Krishna Samanta, Anant B. Parekh

Publikováno v: Current Opinion in Physiology. 17:175-186

A rise in cytosolic Ca2+ concentration is a universal signalling mechanism that regulates myriad physiological responses including exocytosis, contraction, cell growth and cell death. Cytosolic Ca2+ signals often occur in the form of repetitive Ca2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d24bb73eb0a92a1e92e0da90a4a66af
https://doi.org/10.1016/j.cophys.2020.08.011

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

Autor: Johannes Breuning, Kvido Stříšovský, Anant B. Parekh, Yu-Fen Chang, Adam G. Grieve, Nicholas Johnson, Yi Chun Yeh, Matthew Freeman, Lucrezia Zarcone, Marion H. Brown, Hsin-Yi Huang

Publikováno v: Grieve, A G, Yeh, Y-C, Chang, Y-F, Huang, H-Y, Zarcone, L, Breuning, J, Johnson, N, Stříšovský, K, Brown, M H, Parekh, A B & Freeman, M 2021, ' Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation ', Molecular Cell, vol. 81, no. 23, pp. 4784-4798.e7 . https://doi.org/10.1016/j.molcel.2021.10.025

Summary Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell-mediated immunity. Through a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c2455d7d3669ee8075690e54a05e23
https://hdl.handle.net/1983/c64a47d4-d86a-4d6a-89d6-ce7c715c0644

Key role for store-operated Ca2+ channels in activating gene expression in human airway bronchial epithelial cells.

Autor: Krishna Samanta, Daniel Bakowski, Anant B Parekh

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105586 (2014)

Ca2+ entry into airway epithelia is important for activation of the NFAT family of transcription factors and expression of genes including epidermal growth factor that help orchestrate local inflammatory responses. However, the identity of epithelial

Externí odkaz: https://doaj.org/article/5795468b961d4655b195f479740556df