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BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

Autor: Papathanassiu, AE, Ko, JH, Imprialou, M, Bagnati, M, Srivastava, PK, Vu, HA, Cucchi, D, McAdoo, SP, Ananieva, EA, Mauro, C, Behmoaras, JV

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a7548095fc5529e6a5214925055b1aa7
https://doaj.org/article/17c2e0ed5041454ca875e7539e4aa551

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Phenylbutyrate therapy for maple syrup urine disease

Autor: Jun Li, Mohammad Mainul Islam, Juan C. Marini, R. Max Wynn, Nicola Brunetti-Pierri, Madhuri Hegde, Brendan C. Lanpher, Chunli Yu, David T. Chuang, Qin Sun, Ayelet Erez, Elitsa A. Ananieva, Brendan Lee, Susan M. Hutson

Publikováno v: Human molecular genetics. 20(4)

Therapy with sodium phenylacetate/benzoate or sodium phenylbutyrate in urea cycle disorder patients has been associated with a selective reduction in branched-chain amino acids (BCAA) in spite of adequate dietary protein intake. Based on this clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2415fb0fdfb4f477bae38966804c001
https://pubmed.ncbi.nlm.nih.gov/21098507

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Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment.

Autor: Wetzel TJ; Ananieva Laboratory, Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA, United States., Erfan SC; Ananieva Laboratory, Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA, United States., Figueroa LD; Ananieva Laboratory, Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA, United States., Wheeler LM; Ananieva Laboratory, Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA, United States., Ananieva EA; Ananieva Laboratory, Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 May 19; Vol. 13, pp. 1186539. Date of Electronic Publication: 2023 May 19 (Print Publication: 2023).

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The occurrence of bone and joint cancers and their association with rural living and radon exposure in Iowa.

Autor: Nilles JD; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Lim D; Department of Public Health, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Boyer MP; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Wilson BD; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Betar RA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Showalter HA; Waukee Aspiring Professional Experience (APEX), 295 SE Ashworth Road, Waukee, IA, 50263, USA., Liu D; Department of Public Health, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Ananieva EA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA. elitsa.ananieva-stoyanova@dmu.edu.

Publikováno v: Environmental geochemistry and health [Environ Geochem Health] 2023 Mar; Vol. 45 (3), pp. 925-940. Date of Electronic Publication: 2022 Apr 05.

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The emerging role of the branched chain aminotransferases, BCATc and BCATm, for anti-tumor T-cell immunity.

Autor: Wetzel TJ; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, USA., Erfan SC; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, USA., Ananieva EA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, USA.

Publikováno v: Immunometabolism (Cobham, Surrey) [Immunometabolism (Cobham)] 2023 Jan 11; Vol. 5 (1), pp. e00014. Date of Electronic Publication: 2023 Jan 11 (Print Publication: 2023).

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Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling.

Autor: Martin SB; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Reiche WS; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Fifelski NA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Schultz AJ; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Stanford SJ; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Martin AA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Nack DL; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Radlwimmer B; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Boyer MP; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A., Ananieva EA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, U.S.A.

Publikováno v: The Biochemical journal [Biochem J] 2020 May 15; Vol. 477 (9), pp. 1579-1599.

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Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma.

Autor: Ananieva EA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA. elitsa.ananieva-stoyanova@dmu.edu., Bostic JN; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Integrated Life Sciences Building 0913, 1981 Kraft Drive Blacksburg, Blacksburg, VA, 24060, USA.; Centre for Earth Evolution and Dynamics, University of Oslo, N-0315, Oslo, Norway., Torres AA; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Glanz HR; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., McNitt SM; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Brenner MK; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Boyer MP; Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA, 50312, USA., Addington AK; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Integrated Life Sciences Building 0913, 1981 Kraft Drive Blacksburg, Blacksburg, VA, 24060, USA., Hutson SM; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Integrated Life Sciences Building 0913, 1981 Kraft Drive Blacksburg, Blacksburg, VA, 24060, USA.

Publikováno v: British journal of cancer [Br J Cancer] 2018 Oct; Vol. 119 (8), pp. 1009-1017. Date of Electronic Publication: 2018 Oct 15.

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