Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anand Sastry"'
Autor:
Antoine Champie, Jean-Christophe Lachance, Anand Sastry, Dominick Matteau, Colton J. Lloyd, Frédéric Grenier, Cameron R. Lamoureux, Simon Jeanneau, Adam M. Feist, Pierre-Étienne Jacques, Bernhard O. Palsson, Sébastien Rodrigue
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Microorganisms with simplified genomes represent interesting cell chassis for systems and synthetic biology. However, genome reduction can lead to undesired traits, such as decreased growth rate and metabolic imbalances. To investigate the i
Externí odkaz:
https://doaj.org/article/04a55e0de4eb4ac2a7d3e89e6f0be8fb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Understanding how cells dynamically adapt to their environment is a primary focus of biology research. Temporal information about cellular behavior is often limited by both small numbers of data time-points and the methods used to analyze th
Externí odkaz:
https://doaj.org/article/14b89beff4724f58bf77669bda6a26d1
Autor:
Saugat Poudel, Ying Hefner, Richard Szubin, Anand Sastry, Ye Gao, Victor Nizet, Bernhard O. Palsson
Publikováno v:
mSystems, Vol 7, Iss 6 (2022)
ABSTRACT The complex cross talk between metabolism and gene regulatory networks makes it difficult to untangle individual constituents and study their precise roles and interactions. To address this issue, we modularized the transcriptional regulator
Externí odkaz:
https://doaj.org/article/450441b1c32747ac8e7dbc8dc627cd8a
Experimental Evolution Reveals Unifying Systems-Level Adaptations but Diversity in Driving Genotypes
Autor:
Erol S. Kavvas, Christopher P. Long, Anand Sastry, Saugat Poudel, Maciek R. Antoniewicz, Yang Ding, Elsayed T. Mohamed, Richard Szubin, Jonathan M. Monk, Adam M. Feist, Bernhard O. Palsson
Publikováno v:
mSystems, Vol 7, Iss 6 (2022)
ABSTRACT Genotype-fitness maps of evolution have been well characterized for biological components, such as RNA and proteins, but remain less clear for systems-level properties, such as those of metabolic and transcriptional regulatory networks. Here
Externí odkaz:
https://doaj.org/article/583e4c50343e475a9bd6506e2053a0bd
Autor:
Irina A. Rodionova, Ye Gao, Anand Sastry, Ying Hefner, Hyun Gyu Lim, Dmitry A. Rodionov, Milton H. Saier, Bernhard O. Palsson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Rodionova et al. find that the putative transporter gene, ydhC and its regulator ydhB are involved in purine transportation and that the expression of the ydhC gene is activated by the YdhB in E. coli. The authors suggest renaming the regulator PunR
Externí odkaz:
https://doaj.org/article/dda9a19e48a14f5aab67445d3aa0e93c
Publikováno v:
Radiology Case Reports, Vol 17, Iss 2, Pp 290-292 (2022)
Iatrogenic non–thrombotic pulmonary embolism is a rare cause of pulmonary embolism. This case demonstrates the unusual imaging findings associated with pulmonary migration of Precipitating Hydrophobic Injectable Liquid, a liquid embolization materi
Externí odkaz:
https://doaj.org/article/80de785639bb4f67978f0426a8d597f9
Autor:
Reo Yoo, Kevin Rychel, Saugat Poudel, Tahani Al-bulushi, Yuan Yuan, Siddharth Chauhan, Cameron Lamoureux, Bernhard O. Palsson, Anand Sastry
Publikováno v:
mSphere, Vol 7, Iss 2 (2022)
ABSTRACT Mycobacterium tuberculosis is one of the most consequential human bacterial pathogens, posing a serious challenge to 21st century medicine. A key feature of its pathogenicity is its ability to adapt its transcriptional response to environmen
Externí odkaz:
https://doaj.org/article/dcb8bad220fe40899fae48988afddcd3
Autor:
Donghui Choe, Richard Szubin, Saugat Poudel, Anand Sastry, Yoseb Song, Yongjae Lee, Suhyung Cho, Bernhard Palsson, Byung-Kwan Cho
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009821 (2021)
RNA sequencing techniques have enabled the systematic elucidation of gene expression (RNA-Seq), transcription start sites (differential RNA-Seq), transcript 3' ends (Term-Seq), and post-transcriptional processes (ribosome profiling). The main challen
Externí odkaz:
https://doaj.org/article/0b37f4265fd34603afb9aa90ebbc369b
Autor:
Ali Ebrahim, Elizabeth Brunk, Justin Tan, Edward J. O'Brien, Donghyuk Kim, Richard Szubin, Joshua A. Lerman, Anna Lechner, Anand Sastry, Aarash Bordbar, Adam M. Feist, Bernhard O. Palsson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Translating omics data sets into biological insight is one of the great challenges of our time. Here, the authors make headway by synchronising pairs of omics data types via invariants across conditions and by integrating datasets into a genome-scale
Externí odkaz:
https://doaj.org/article/54b0e226f9794904895aa0e7518d169f
Autor:
Joon Young Park, Sang-Mok Lee, Ali Ebrahim, Zoe K Scott-Nevros, Jaehyung Kim, Laurence Yang, Anand Sastry, Sang Woo Seo, Bernhard O Palsson, Donghyuk Kim
Publikováno v:
Park, J Y, Lee, S-M, Ebrahim, A, Scott-Nevros, Z K, Kim, J, Yang, L, Sastry, A, Seo, S W, Palsson, B O & Kim, D 2023, ' Model-driven experimental design workflow expands understanding of regulatory role of Nac in Escherichia coli ', NAR Genomics and Bioinformatics, vol. 5, no. 1 . https://doi.org/10.1093/nargab/lqad006
The establishment of experimental conditions for transcriptional regulator network (TRN) reconstruction in bacteria continues to be impeded by the limited knowledge of activating conditions for transcription factors (TFs). Here, we present a novel ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291867d06d3ff61e440fcb937f7572f5
https://doi.org/10.1093/nargab/lqad006
https://doi.org/10.1093/nargab/lqad006