Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anand Rajarethinam"'
Autor:
Mrinal M. Gounder, Thierry Jahan, Tom Wei-Wu Chen, Lara E. Davis, Silvia Stacchiotti, Victor M. Villalobos, Mark Agulnik, Olivier Mir, Antoine Italiano, Anand Rajarethinam, Ravin Ratan, Abha A. Gupta, Robin L. Jones, Rashmi Chugh, Laura Sierra, George D. Demetri, Steven Attia, Elizabeth T. Loggers, Gregory M. Cote, Joseph G. Pressey, P. Dileo, Brian A. Van Tine, Patrick Schöffski, Shefali Agarwal, Trupti Lingaraj
Publikováno v:
The Lancet Oncology. 21:1423-1432
Summary Background Epithelioid sarcoma is a rare and aggressive soft-tissue sarcoma subtype. Over 90% of tumours have lost INI1 expression, leading to oncogenic dependence on the transcriptional repressor EZH2. In this study, we report the clinical a
Autor:
Jay Yang, Mrinal M. Gounder, Shreyaskumar Patel, Anand Rajarethinam, Angela Lax, Priscilla Merriam, Victor M. Villalobos, Amr Hesham Abdelhamid, Jennifer Whalen, Todor Totev, Lynn Huynh, Mei Sheng Duh, Priyanka Bobbili, George D. Demetri, Shefali Agarwal, Rashmi Chugh, Brian A. Van Tine, Mark Thornton, Ravin Ratan
Publikováno v:
Cancer
Background Limited data are available on the real‐world effectiveness and safety of systemic therapies for advanced (surgically unresectable and/or metastatic) epithelioid sarcoma (ES). Methods A retrospective medical records review was conducted i
Autor:
Aristeidis Chaidos, Jennifer Whalen, John Radford, Susan Benedict Navia, Gilles Salles, Pamela McKay, Damaj Gandhi Laurent, Anand Rajarethinam, Hervé Tilly, Vincent Ribrag, Stephen Opat, Tycel Phillips, Franck Morschhauser, Philip Campbell, Wojciech Jurczak, Deyaa Adib
Publikováno v:
Blood. 134:123-123
Introduction: Relapsed/refractory (R/R) follicular lymphoma (FL) remains a difficult-to-treat condition, with limited treatment options. New, tolerable treatments with unique mechanisms of action are needed, especially for high-risk patients whose di
Autor:
Jennifer Whalen, Amr Hesham Abdelhamid, P. Joshi, Anand Rajarethinam, C.L. Cavanaugh, Priyanka Bobbili, George D. Demetri, Ravin Ratan, Todor Totev, Rashmi Chugh, Priscilla Merriam, Shreyaskumar Patel, Mei Sheng Duh, B.A. Van Tine, Mrinal M. Gounder, Victor M. Villalobos, Jay Yang, M. Thorton, Lynn Huynh
Publikováno v:
Annals of Oncology. 30:v692
Background Limited data are available on effectiveness and safety of systemic therapies for treatment of advanced (unresectable and/or metastatic) epithelioid sarcoma (ES). This natural history study collected real-world (rw) data on outcomes of ES p
Autor:
Thierry Jahan, Mark Agulnik, Anand Rajarethinam, Steven Attia, Robin L. Jones, George D. Demetri, Mrinal M. Gounder, Antoine Italiano, Brian A. Van Tine, Abha A. Gupta, Rashmi Chugh, Tom Wei-Wu Chen, Gregory M. Cote, Victor M. Villalobos, Jay Yang, Patrick Schöffski, Laura Sierra, Elizabeth T. Loggers, Silvia Stacchiotti
Publikováno v:
Journal of Clinical Oncology. 37:11003-11003
11003 Background: ES is a rare soft tissue sarcoma that metastasizes in approximately 30% to 50% of cases. More than 90% of ES tumors lack expression of INI1, an important component of epigenetic regulation. Loss of INI1 function allows another epige