Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Anand Kumar Katakam"'
1
Akademický článek
EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
Autor: Ariel Pribluda, Anneleen Daemen, Anthony Nelson Lima, Xi Wang, Marc Hafner, Chungkee Poon, Zora Modrusan, Anand Kumar Katakam, Oded Foreman, Jefferey Eastham, Jefferey Hung, Benjamin Haley, Julia T Garcia, Erica L Jackson, Melissa R Junttila
Publikováno v: eLife, Vol 11 (2022)
Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that EHMT2 methyltransferase regulates Wnt signaling in the lung by controlling the transcriptional acti
Externí odkaz: https://doaj.org/article/2f31c92d4ffd432aa51ebba9e6618753
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2
Akademický článek
Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response
Autor: Timurs Maculins, Erik Verschueren, Trent Hinkle, Meena Choi, Patrick Chang, Cecile Chalouni, Shilpa Rao, Youngsu Kwon, Junghyun Lim, Anand Kumar Katakam, Ryan C Kunz, Brian K Erickson, Ting Huang, Tsung-Heng Tsai, Olga Vitek, Mike Reichelt, Yasin Senbabaoglu, Brent Mckenzie, John R Rohde, Ivan Dikic, Donald S Kirkpatrick, Aditya Murthy
Publikováno v: eLife, Vol 10 (2021)
Defective autophagy is strongly associated with chronic inflammation. Loss-of-function of the core autophagy gene Atg16l1 increases risk for Crohn’s disease in part by enhancing innate immunity through myeloid cells such as macrophages. However, au
Externí odkaz: https://doaj.org/article/f7e6c7d1cf284be89aa3c3ebd2cb98db
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3
Akademický článek
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase
Autor: Homer Pantua, Elizabeth Skippington, Marie-Gabrielle Braun, Cameron L. Noland, Jingyu Diao, Yutian Peng, Susan L. Gloor, Donghong Yan, Jing Kang, Anand Kumar Katakam, Janina Reeder, Georgette M. Castanedo, Keira Garland, Laszlo Komuves, Meredith Sagolla, Cary D. Austin, Jeremy Murray, Yiming Xu, Zora Modrusan, Min Xu, Emily J. Hanan, Sharookh B. Kapadia
Publikováno v: mBio, Vol 11, Iss 5 (2020)
ABSTRACT Clinical development of antibiotics with novel mechanisms of action to kill pathogenic bacteria is challenging, in part, due to the inevitable emergence of resistance. A phenomenon of potential clinical importance that is broadly overlooked
Externí odkaz: https://doaj.org/article/ad7dc0127d394ca78d233d455e860331
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4
Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii
Autor: Ke-Jung Huang, Homer Pantua, Jingyu Diao, Elizabeth Skippington, Michael Volny, Wendy Sandoval, Varnesh Tiku, Yutian Peng, Meredith Sagolla, Donghong Yan, Jing Kang, Anand Kumar Katakam, Nairie Michaelian, Mike Reichelt, Man-Wah Tan, Cary D. Austin, Min Xu, Emily Hanan, Sharookh B. Kapadia
Publikováno v: Proceedings of the National Academy of Sciences. 119
Acinetobacter baumannii is a clinically important, predominantly health care–associated gram-negative bacterium with high rates of emerging resistance worldwide. Given the urgent need for novel antibacterial therapies against A. baumannii , we focu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d0dc82e096281ab4df29647d2a70859
https://doi.org/10.1073/pnas.2123117119
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6
Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs
Autor: Roxanne Andaya, F. Anthony Romero, Paula Katavolos, Anand Kumar Katakam, Edna F. Choo, Gary Cain, Steven Magnuson, Jonathan Maher, Cindy Farman, Justin Ly
Publikováno v: Toxicologic Pathology. 48:465-480
Cyclic adenosine monophosphate-response element (CREB)-binding protein (CBP) and EP300E1A-binding protein (p300) are members of the bromodomain and extraterminal motif (BET) family. These highly homologous proteins have a key role in modulating trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c290f02af0cd42a80474a188284c6b4f
https://doi.org/10.1177/0192623319898469
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10
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage
Autor: Qui T. Phung, Stefan Gerhardy, Mike Reichelt, Michele A. Grimbaldeston, Lucinda W Tam, Patrick Caplazi, Alvin Gogineni, Andrew P. AhYoung, Christian Cox, Robby M. Weimer, Daniel Kirchhofer, Jason A. Hackney, Sterling C Eckard, Wyne P. Lee, Robert J. Newman, Merone Roose-Girma, Jennie R. Lill, Anand Kumar Katakam, Hongkang Xi, Juan Zhang, Aditya Murthy, S. Jack Lin, Paolo Manzanillo, Menno Van Lookeren Campagne
Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Vascular leakage, or edema, is a serious complication of acute allergic reactions. Vascular leakage is triggered by the release of histamine and serotonin from granules within tissue-resident mast cells. Here, we show that expression of Neutrophil Se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb8ab7369d74edd5e6fbbd487e963fe
https://doi.org/10.1038/s42003-020-01407-0
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