Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Anand Kumar Andiappan"'
Autor:
Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger, Olaf Rötzschke
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, which potentially allow f
Externí odkaz:
https://doaj.org/article/6789065dca8a4f8b9135ff6219aef723
Autor:
Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of
Externí odkaz:
https://doaj.org/article/c143d737821c4b528b01c70d7893f2f4
Autor:
Guillaume Carissimo, Weili Xu, Immanuel Kwok, Mohammad Yazid Abdad, Yi-Hao Chan, Siew-Wai Fong, Kia Joo Puan, Cheryl Yi-Pin Lee, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Rhonda Sin-Ling Chee, Wilson How, Stephrene Chan, Bingwen Eugene Fan, Anand Kumar Andiappan, Bernett Lee, Olaf Rötzschke, Barnaby Edward Young, Yee-Sin Leo, David Chien Lye, Laurent Renia, Lai Guan Ng, Anis Larbi, Lisa FP Ng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-
Externí odkaz:
https://doaj.org/article/d967340f6639442885027de8b53a2e43
Autor:
Jackwee Lim, Kia Joo Puan, Liang Wei Wang, Karen Wei Weng Teng, Chiew Yee Loh, Kim Peng Tan, Guillaume Carissimo, Yi-Hao Chan, Chek Meng Poh, Cheryl Yi-Pin Lee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Rhonda Sin-Ling Chee, Siti Naqiah Amrun, Zi Wei Chang, Matthew Zirui Tay, Anthony Torres-Ruesta, Norman Leo Fernandez, Wilson How, Anand Kumar Andiappan, Wendy Lee, Kaibo Duan, Seow-Yen Tan, Gabriel Yan, Shirin Kalimuddin, David Chien Lye, Yee-Sin Leo, Sean W. X. Ong, Barnaby E. Young, Laurent Renia, Lisa F. P. Ng, Bernett Lee, Olaf Rötzschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected
Externí odkaz:
https://doaj.org/article/09415a4209cb486cbf1d519aa8d7c6ff
Autor:
Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré, Don D. Sin
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death and there is a huge unmet clinical need to identify disease biomarkers in peripheral blood. Compared to gene level differential expression
Externí odkaz:
https://doaj.org/article/14821bba095a4017aeacc69c0fa6fb4d
Autor:
Dilip Kumar, Kia Joo Puan, Anand Kumar Andiappan, Bernett Lee, Geertje H. A. Westerlaken, Doreen Haase, Rossella Melchiotti, Zhuang Li, Nurhashikin Yusof, Josephine Lum, Geraldine Koh, Shihui Foo, Joe Yeong, Alexessander Couto Alves, Juha Pekkanen, Liang Dan Sun, Astrid Irwanto, Benjamin P. Fairfax, Vivek Naranbhai, John E. A. Common, Mark Tang, Chin Keh Chuang, Marjo-Riitta Jarvelin, Julian C. Knight, Xuejun Zhang, Fook Tim Chew, Shyam Prabhakar, Liu Jianjun, De Yun Wang, Francesca Zolezzi, Michael Poidinger, E. Birgitte Lane, Linde Meyaard, Olaf Rötzschke
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-16 (2017)
Abstract Background Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation. We prev
Externí odkaz:
https://doaj.org/article/5e11065b92e948459f1e77a7ba21067a
Autor:
Sri Anusha Matta, Sandrine Blanchet-Rethore, Yang Yie Sio, Bani Kaur Suri, Anand Kumar Andiappan, Ramani Anantharaman, Christophe Piketty, Valerie Bourdes, Fook Tim Chew
Publikováno v:
World Allergy Organization Journal, Vol 12, Iss 1, Pp - (2019)
Background: Atopic dermatitis (AD) is a chronic allergic disease typically accompanied by atopy and thus, a tendency to develop allergic diseases such as allergic rhinitis, asthma or food allergies. Currently, individuals with AD are classified into
Externí odkaz:
https://doaj.org/article/f64d56f51f8e411b985a0d38d74941fd
Autor:
Kai Sen Tan, Anand Kumar Andiappan, Bernett Lee, Yan Yan, Jing Liu, See Aik Tang, Josephine Lum, Ting Ting He, Yew Kwang Ong, Mark Thong, Hui Fang Lim, Hyung Won Choi, Olaf Rotzschke, Vincent T Chow, De Yun Wang
Publikováno v:
Cells, Vol 8, Iss 9, p 986 (2019)
The human nasal epithelium is the primary site of exposure to influenza virus, the initiator of host responses to influenza and the resultant pathologies. Influenza virus may cause serious respiratory infection resulting in major complications, as we
Externí odkaz:
https://doaj.org/article/6281ea9ac8104afc8eaa166cf5bc8eb2
Autor:
Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R Wood, David Melzer, Luigi Ferrucci, Andrew B Singleton, Dena G Hernandez, Julian C Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, De Yun Wang, Leonard H van den Berg, Jan H Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B J van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C Jansen, Lude Franke
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005223 (2015)
The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may no
Externí odkaz:
https://doaj.org/article/326fb91a6b344710813ff767ee21efa8
Autor:
Daniel Nilsson, Anand Kumar Andiappan, Christer Halldén, Chew Fook Tim, Torbjörn Säll, De Yun Wang, Lars-Olaf Cardell
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53975 (2013)
Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate th
Externí odkaz:
https://doaj.org/article/153e40d670774e2fb2e84fcc6876f0d9