Výsledky vyhledávání - "Anand K. Muthusamy"

Akademický článek

Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum

Autor: Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

The target for the “rapid” (100-fold selectivity over other ligands tested, including R-ketamine. We targeted each of the sensors to either the plasma membrane (PM) or the endoplasmic reticulum (ER). Measurements on these biosensors expressed in

Externí odkaz: https://doaj.org/article/4397d649b8754ebaa97c121f59eaa73b

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Akademický článek

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

Autor: Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester

Publikováno v: eLife, Vol 11 (2022)

Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell

Externí odkaz: https://doaj.org/article/4b4e86491b454335b0724b76381431a8

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Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane

Autor: Aaron L. Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J. Knox, Anand K. Muthusamy, Jonathan S. Marvin, Charlene H. Kim, Stephen N. Grant, David P. Walton, Bruce N. Cohen, Rebekkah Hammar, Loren L. Looger, Per Artursson, Dennis A. Dougherty, Henry A. Lester

Publikováno v: Journal of Neuroscience
bioRxiv

Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder (MDD). The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin transporter (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b270db0c9b8f16cd7ed2f4edcd6f0794

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Akademický článek

Nuclear microenvironments modulate transcription from low-affinity enhancers

Autor: Albert Tsai, Anand K Muthusamy, Mariana RP Alves, Luke D Lavis, Robert H Singer, David L Stern, Justin Crocker

Publikováno v: eLife, Vol 6 (2017)

Transcription factors bind low-affinity DNA sequences for only short durations. It is not clear how brief, low-affinity interactions can drive efficient transcription. Here, we report that the transcription factor Ultrabithorax (Ubx) utilizes low-aff

Externí odkaz: https://doaj.org/article/a145c2cd935c4eba81ff6c682d5bea35

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Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids

Autor: Anand K. Muthusamy, Charlene H. Kim, Scott C. Virgil, Hailey J. Knox, Jonathan S. Marvin, Aaron L. Nichols, Bruce N. Cohen, Dennis A. Dougherty, Loren L. Looger, Henry A. Lester

Publikováno v: Journal of the American Chemical Society, vol 144, iss 19

We report a reagentless, intensity-based S-methadone fluorescent sensor, iS-methadoneSnFR, consisting of a circularly permuted GFP inserted within the sequence of a mutated bacterial periplasmic binding protein (PBP). We evolved a previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53972a94019485a4a65506408d036e07
https://resolver.caltech.edu/CaltechAUTHORS:20220228-619163000

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Fluorescence Screens for Identifying Central Nervous System–Acting Drug–Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics

Autor: Zoe G, Beatty, Anand K, Muthusamy, Elizabeth K, Unger, Dennis A, Dougherty, Lin, Tian, Loren L, Looger, Amol V, Shivange, Kallol, Bera, Henry A, Lester, Aaron L, Nichols

Publikováno v: Bio Protoc

Subcellular pharmacokinetic measurements have informed the study of central nervous system (CNS)–acting drug mechanisms. Recent investigations have been enhanced by the use of genetically encoded fluorescent biosensors for drugs of interest at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9580feacb1a6314be6428bdfaea0719d
https://doi.org/10.21769/bioprotoc.4551

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Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

Autor: Laura Luebbert, Chengcheng Fan, Zack Blumenfeld, Aaron L Nichols, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester

Publikováno v: eLife, Vol 11 (2022)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5443311f3c81c64be58edbae07c241
https://elifesciences.org/articles/74648

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