Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Anand K, Ganesan"'
2
Akademický článek
Multimodal analyses of vitiligo skin identifies tissue characteristics of stable disease
Autor: Jessica Shiu, Lihua Zhang, Griffin Lentsch, Jessica L. Flesher, Suoqin Jin, Christopher Polleys, Seong Jin Jo, Craig Mizzoni, Pezhman Mobasher, Jasmine Kwan, Francisca Rius-Diaz, Bruce J. Tromberg, Irene Georgakoudi, Qing Nie, Mihaela Balu, Anand K. Ganesan
Publikováno v: JCI Insight, Vol 7, Iss 13 (2022)
Vitiligo is an autoimmune skin disease characterized by the destruction of melanocytes by autoreactive CD8+ T cells. Melanocyte destruction in active vitiligo is mediated by CD8+ T cells, but the persistence of white patches in stable disease is poor
Externí odkaz: https://doaj.org/article/70db2878d8444c468566494231468fe7
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3
Akademický článek
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
Autor: Sohail Jahid, Jose A. Ortega, Linh M. Vuong, Isabella Maria Acquistapace, Stephanie J. Hachey, Jessica L. Flesher, Maria Antonietta La Serra, Nicoletta Brindani, Giuseppina La Sala, Jacopo Manigrasso, Jose M. Arencibia, Sine Mandrup Bertozzi, Maria Summa, Rosalia Bertorelli, Andrea Armirotti, Rongsheng Jin, Zheng Liu, Chi-Fen Chen, Robert Edwards, Christopher C.W. Hughes, Marco De Vivo, Anand K. Ganesan
Publikováno v: Cell Reports, Vol 39, Iss 1, Pp 110641- (2022)
Summary: CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here, we use computer
Externí odkaz: https://doaj.org/article/b20a95d5a6444819bbfaaf7b0c218769
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5
Akademický článek
Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes
Autor: Rolando Ruiz-Vega, Chi-Fen Chen, Emaad Razzak, Priya Vasudeva, Tatiana B Krasieva, Jessica Shiu, Michael G Caldwell, Huaming Yan, John Lowengrub, Anand K Ganesan, Arthur D Lander
Publikováno v: eLife, Vol 9 (2020)
Mutational activation of the BRAF proto-oncogene in melanocytes reliably produces benign nevi (pigmented ‘moles’), yet the same change is the most common driver mutation in melanoma. The reason nevi stop growing, and do not progress to melanoma,
Externí odkaz: https://doaj.org/article/ebbfba30db8a42e8b8e4e0ad08a82c27
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6
Akademický článek
ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment
Autor: Chi-Fen Chen, Rolando Ruiz-Vega, Priya Vasudeva, Francisco Espitia, Tatiana B. Krasieva, Sebastien de Feraudy, Bruce J. Tromberg, Sharon Huang, Chad P. Garner, Jie Wu, Dave S. Hoon, Anand K. Ganesan
Publikováno v: Cell Reports, Vol 18, Iss 10, Pp 2331-2342 (2017)
Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mu
Externí odkaz: https://doaj.org/article/89cbe74ce62943d1b1e7f21acc739c0e
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7
Alchemical Free Energy Calculations to Investigate Protein–Protein Interactions: the Case of the CDC42/PAK1 Complex
Autor: Maria Antonietta La Serra, Pietro Vidossich, Isabella Acquistapace, Anand K. Ganesan, Marco De Vivo
Publikováno v: Journal of chemical information and modeling, vol 62, iss 12
Here, we show that alchemical free energy calculations can quantitatively compute the effect of mutations at the protein-protein interface. As a test case, we have used the protein complex formed by the small Rho-GTPase CDC42 and its downstream effec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c614a3ffd87e4d9e5d6ff381a6a4d6f9
https://doi.org/10.1021/acs.jcim.2c00348
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