Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anand Divakaran"'
Publikováno v:
Medicinal Research Reviews.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6d64d10ce15240ae626e30cac8eccc
https://doi.org/10.1002/med.21942
https://doi.org/10.1002/med.21942
Autor:
Huarui Cui, Anand Divakaran, Zachariah J. Hoell, Mikael O. Ellingson, Cole R. Scholtz, Huda Zahid, Jorden A. Johnson, Elizabeth C. Griffith, Clifford T. Gee, Amani L. Lee, Shalil Khanal, Ke Shi, Hideki Aihara, Vijay H. Shah, Richard E. Lee, Daniel A. Harki, William C. K. Pomerantz
Publikováno v:
J Med Chem
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b7a4c86e5079b9c8290b3133b80308
https://pubmed.ncbi.nlm.nih.gov/35007061
https://pubmed.ncbi.nlm.nih.gov/35007061
Autor:
Huda Zahid, Wenwei Lin, Anand Divakaran, Daniel A. Harki, Taosheng Chen, William C. K. Pomerantz
Targeted protein degradation is a powerful induced-proximity tool to control cellular concentrations of native proteins using small molecules. However, the design of selectivity in protein degradation remains challenging. In the case of Bromodomain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679319e949e9d1c9719097be01674f53
https://doi.org/10.33774/chemrxiv-2021-zvq4t
https://doi.org/10.33774/chemrxiv-2021-zvq4t
Autor:
William C. K. Pomerantz, Huarui Cui, Nora R. Vail, Ke Shi, Anand Divakaran, Jorden A. Johnson, Huda Zahid, Grover P. Miller, Daniel A. Harki, Joseph J. Topczewski, Caroline R. Buchholz, Hideki Aihara, Mary A. Schleiff, Angela S. Carlson
Publikováno v:
J Med Chem
The bromodomain and extra terminal (BET) protein family recognizes acetylated lysines within histones and transcription factors using two N-terminal bromodomains, D1 and D2. The protein–protein interactions between BET bromodomains, acetylated hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7902ab86e4ce714d58bf51d36986f5
https://europepmc.org/articles/PMC8491147/
https://europepmc.org/articles/PMC8491147/
Publikováno v:
Accounts of Chemical Research. 52:3407-3418
Inhibitor discovery for protein-protein interactions has proven difficult due to the large protein surface areas and dynamic interfaces involved. This is particularly the case when targeting transcription-factor-protein interactions. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4d52f46328e9ce672f8b416f0c12fe
https://doi.org/10.1021/acs.accounts.9b00377
https://doi.org/10.1021/acs.accounts.9b00377
Autor:
William C. K. Pomerantz, Anand Divakaran, Prakriti Kalra, Jonathan Solberg, Huarui Cui, Jon E. Hawkinson, Kristen John, Anil K. Pandey, Logan McGraw, Jennifer R. Kimbrough
Publikováno v:
ACS Chem Biol
Multidomain bromodomain-containing proteins regulate gene expression via chromatin binding, interactions with the transcriptional machinery, and by recruiting enzymatic activity. Selective inhibition of members of the bromodomain and extra-terminal (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151478fda9bef7e98a337945fb84423b
https://europepmc.org/articles/PMC8185897/
https://europepmc.org/articles/PMC8185897/
Autor:
Anand Divakaran, Jorden A. Johnson, Ke Shi, Huarui Cui, Hideki Aihara, Daniel A. Harki, Anil K. Pandey, Mikael O Ellingson, Huda Zahid, William C. K. Pomerantz, Zachariah J Hoell
Publikováno v:
Angew Chem Int Ed Engl
Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET bromodomain are lacking, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b79da71e3806f7d8c1a0a9ceab6903e
https://pubmed.ncbi.nlm.nih.gov/32975004
https://pubmed.ncbi.nlm.nih.gov/32975004
Autor:
Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz
This manuscript focuses on the structure-based design of selective inhibitors of the first bromodomain of BRD4. This manuscript uses describes organic synthesis to make inhibitors, and biophysical analysis to evaluate their inhibitor potency in compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6977776df1ca078d9f50c57a6f3cfb80
https://doi.org/10.26434/chemrxiv.12156747
https://doi.org/10.26434/chemrxiv.12156747
Publikováno v:
Acc Chem Res
Inhibitor discovery for protein–protein interactions has proven difficult due to the large protein surface areas and dynamic interfaces involved. This is particularly the case when targeting transcription-factor–protein interactions. To address t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0fdb36b5b4c7ed51f184f433bee9c19
https://pubmed.ncbi.nlm.nih.gov/31718149
https://pubmed.ncbi.nlm.nih.gov/31718149
Autor:
Anand Divakaran, Jorden A. Johnson, Huarui Cui, Joseph J. Topczewski, Ryan M. Brunner, William C. K. Pomerantz, Angela S. Carlson
Publikováno v:
ACS Med Chem Lett
[Image: see text] The Bromodomain and Extra Terminal (BET) family of proteins recognize post-translational N-ε-acetylated lysine modifications, regulating transcription as “reader” proteins. Bromodomain inhibitors are interesting targets for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e783dd23464964462a8c47c6d90cf5
https://pubmed.ncbi.nlm.nih.gov/31531200
https://pubmed.ncbi.nlm.nih.gov/31531200