Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Anand D. Tiwari"'
Autor:
Yihong Guan, Metis Hasipek, Dongxu Jiang, Anand D. Tiwari, Dale R. Grabowski, Simona Pagliuca, Sunisa Kongkiatkamon, Bhumika Patel, Salendra Singh, Yvonne Parker, Thomas LaFramboise, Daniel Lindner, Mikkael A. Sekeres, Omar Y. Mian, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Babal K. Jha
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Eltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically used for the treatment of aplastic anemia, a disease characterized by hematopoietic stem cell failure and pancytopenia, to improve platelet counts and stem cell
Externí odkaz:
https://doaj.org/article/33fa0ff209d24e1aaf2609619eadb9c2
Autor:
Siva S. Panda, Sumaira Liaqat, Anand D. Tiwari, Hadi M. Marwani, Hassan M. Faidallah, Abdul Rauf, C. Dennis Hall, Alan R. Katritzky
Publikováno v:
ARKIVOC, Vol 2015, Iss 4, Pp 9-18 (2014)
Externí odkaz:
https://doaj.org/article/408f20ac162c41fead5d3238791db4e1
Autor:
Danai Dima, Metis Hasipek, Divya Jyoti Singh, Dongxu Jiang, Anand D. Tiwari, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Jianjun Zhao, Kenneth H. Shain, Jack Khouri, Jaroslaw P. Maciejewski, Babal K. Jha
Publikováno v:
Blood. 140:7100-7101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7839473f7cc4f595e7efb63499e85b9
https://doi.org/10.1182/blood-2022-169516
https://doi.org/10.1182/blood-2022-169516
Autor:
Metis Hasipek, Cassandra M Kerr, Vera Adema, Babal K. Jha, Yihong Guan, Daniel J. Lindner, Anand D. Tiwari, Manja Meggendorfer, Tomas Radivoyevitch, Mohamed E. Abazeed, Dale Grabowski, Yvonne Parker, Priyanka Gopal, Omar Y. Mian, Jaroslaw P. Maciejewski, Mikkeal A. Sekeres, Simona Pagliuca, James G. Phillips, Torsten Haferlach
Publikováno v:
Blood Cancer Discov
TET2 is frequently mutated in myeloid neoplasms. Genetic TET2 deficiency leads to skewed myeloid differentiation and clonal expansion, but minimal residual TET activity is critical for survival of neoplastic progenitor and stem cells. Consistent with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847c1d2e77a5082212864350b8dc7f93
https://doi.org/10.1158/2643-3230.bcd-20-0173
https://doi.org/10.1158/2643-3230.bcd-20-0173
Autor:
Bin Wang, Xizhen Wang, Jingqiang You, Chunying Wu, Yanming Wang, Jinle Zhu, Jerry Silver, Anand D. Tiwari, Xu Wang, Junqing Zhu, Brendan L. Eck, David Wilson
Publikováno v:
Journal of Medicinal Chemistry. 62:4902-4914
Myelin is the protective sheath that surrounds nerves in vertebrates to protect axons, which thereby facilitates impulse conduction. Damage to myelin is associated with many neurodegenerative disea...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b52fc1bdfc39b92338387ab4cc70ea
https://doi.org/10.1021/acs.jmedchem.8b01354
https://doi.org/10.1021/acs.jmedchem.8b01354
Autor:
Yihong Guan, Babal K. Jha, Dale Grabowski, Raghunandan Reddy Alugubelli, Gabriel DeAvila, Kenneth H. Shain, Daniel J. Lindner, Xiaorong Gu, Yogen Saunthararajah, Metis Hasipek, Anand D. Tiwari, Jaroslaw P. Maciejewski, Frederic J. Reu, James G. Phillips, Yvonne Parker, Ariosto S. Silva, Mark B. Meads
Publikováno v:
Cancers
Volume 13
Issue 11
Cancers, Vol 13, Iss 2649, p 2649 (2021)
Volume 13
Issue 11
Cancers, Vol 13, Iss 2649, p 2649 (2021)
Simple Summary Multiple myeloma (MM) is a cancer of antibody-producing plasma cells that remains incurable. These cells heavily depend on protein disulfide isomerase, PDIA1, for folding and structural integrity of antibodies and other secretory prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ca14d5e1aac4b0fb7f2eb0500d8a6
https://pubmed.ncbi.nlm.nih.gov/34071205
https://pubmed.ncbi.nlm.nih.gov/34071205
Publikováno v:
Semin Hematol
TET2 is one of the most frequently mutated genes in myeloid neoplasms. TET2 loss-of-function perturbs myeloid differentiation and causes clonal expansion. Despite extensive knowledge regarding biochemical mechanisms underlying distorted myeloid diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad6f2307793a035d0346c8d2286ad9e
https://europepmc.org/articles/PMC7938524/
https://europepmc.org/articles/PMC7938524/
Autor:
Khalid A. Khan, Amany M.M. Al-Mahmoudy, Abdullah M. Asiri, Hassan M. Faidallah, Ahmed Samir, Khalid A. Alamry, Tarek S. Ibrahim, Sean J. Thomas, Siva S. Panda, Hitesh H. Honkanadavar, Adel S. Girgis, Anand D. Tiwari, Atef Kalmouch
Publikováno v:
European Journal of Medicinal Chemistry. 143:1524-1534
A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10–15, 17–19 were synthesized via microwave assisted click chemistry technique. Some of the aryl-substituted conjugates 17–19 show promising antibacterial properties against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e0ecc501011eaf2b40e747271cf469
https://doi.org/10.1016/j.ejmech.2017.10.042
https://doi.org/10.1016/j.ejmech.2017.10.042
Autor:
Metis Hasipek, Yihong Guan, Omar Y. Mian, Daniel J. Lindner, Dale Grabowski, Jaroslaw P. Maciejewski, Anand D. Tiwari, Babal K. Jha, Mingjiang Xu, James G. Phillips
Publikováno v:
Blood. 138:3985-3985
Background: TET-dioxygenases (TET1, TET2, and TET3) are key epigenetic regulators, which require molecular oxygen, αKG, and Fe 2+ to progressively oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f898cb320fbf222f19b6326182fffca6
https://doi.org/10.1182/blood-2021-152744
https://doi.org/10.1182/blood-2021-152744
Autor:
Yifan Zhang, Xu Wang, Yunjie Zhu, Junqing Zhu, Xin Yu, Robert H. Miller, David L. Wilson, Bin Wang, Sheng Zhang, Xizhen Wang, Chunying Wu, Yanming Wang, Xingdang Liu, Brendan L. Eck, Jinming Zhang, Yihui Guan, Jingqiang You, Bruce D. Trapp, Anand D. Tiwari, Jerry Silver, Jian Wang
Publikováno v:
Journal of Medicinal Chemistry. 60:987-999
Myelin pathology is present in many neurological conditions such as multiple sclerosis (MS) and traumatic spinal cord injury (SCI). To facilitate development of novel therapies aimed at myelin repair, we set out to develop imaging agents that permit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05f5e15a3c7d22bc94b55b92d6b455
https://doi.org/10.1021/acs.jmedchem.6b01328
https://doi.org/10.1021/acs.jmedchem.6b01328