Zobrazeno 1 - 10
of 582
pro vyhledávání: '"Anand Swaroop"'
Autor:
Jayshree Advani, Puja A. Mehta, Andrew R. Hamel, Sudeep Mehrotra, Christina Kiel, Tobias Strunz, Ximena Corso-Díaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Emily Y. Chew, Dena G. Hernandez, Sandra R. Montezuma, Deborah A. Ferrington, Bernhard H. F. Weber, Ayellet V. Segrè, Anand Swaroop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract DNA methylation provides a crucial epigenetic mark linking genetic variations to environmental influence. We have analyzed array-based DNA methylation profiles of 160 human retinas with co-measured RNA-seq and >8 million genetic variants, un
Externí odkaz:
https://doaj.org/article/8d47fc27aef84583ace1428d94cd4bdd
Autor:
Andrew R. Hamel, Wenjun Yan, John M. Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A. Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R. Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P. Khawaja, Stuart MacGregor, International Glaucoma Genetics Consortium (IGGC), Rui Chen, Veronique Vitart, Joshua R. Sanes, Janey L. Wiggs, Ayellet V. Segrè
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP)
Externí odkaz:
https://doaj.org/article/7f45f11f740249d881e78d06fd091c4e
Publikováno v:
Fuzzy Information and Engineering, Vol 15, Iss 4, Pp 313-323 (2023)
In this paper, we develop a systematic theory for the ideals of an L-ring L(μ, R). We introduce the concepts of a prime ideal, a semiprime ideal, and the radical of an ideal in an L-ring. The notion of a maximal ideal has been introduced and discuss
Externí odkaz:
https://doaj.org/article/b973352870124e6686533b73829bbc32
Publikováno v:
Fuzzy Information and Engineering, Vol 15, Iss 4, Pp 324-334 (2023)
In this paper, a systematic theory for the ideals of an L-ring L(μ,R) has been developed. Earlier the authors have introduced the concepts of prime ideals, semiprime ideals, primary ideals, and radical of an ideal in an L-ring. They have also introd
Externí odkaz:
https://doaj.org/article/dbd97482025c48be8f7aeb754f7fb295
Autor:
Anupam K. Mondal, Daniel C. Brock, Sheldon Rowan, Zhi-Hong Yang, Krishna Vamsi Rojulpote, Kelsey M. Smith, Sarah G. Francisco, Eloy Bejarano, Milton A. English, Amy Deik, Sarah Jeanfavre, Clary B. Clish, Alan T. Remaley, Allen Taylor, Anand Swaroop
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108979- (2024)
Summary: A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In
Externí odkaz:
https://doaj.org/article/b13e6864cc514103b6dadb00ab4c518b
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113543- (2023)
Summary: We have generated a high-resolution Hi-C map of developing human retinal organoids to elucidate spatiotemporal dynamics of genomic architecture and its relationship with gene expression patterns. We demonstrate progressive stage-specific alt
Externí odkaz:
https://doaj.org/article/5e01e1ec43cd464b9283111e41a31196
Autor:
Zhi-Hong Yang, Aruna Gorusupudi, Todd A. Lydic, Anupam K. Mondal, Seizo Sato, Isao Yamazaki, Hideaki Yamaguchi, Jingrong Tang, Krishna Vamsi Rojulpote, Anna B. Lin, Hannah Decot, Hannah Koch, Daniel C. Brock, Ranganathan Arunkumar, Zhen-Dan Shi, Zu-Xi Yu, Milton Pryor, Julia F. Kun, Rolf E. Swenson, Anand Swaroop, Paul S. Bernstein, Alan T. Remaley
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108411- (2023)
Summary: Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field. We produced an n-3 C24-28-ri
Externí odkaz:
https://doaj.org/article/74a7d220a4254a238343bbd4e714de34
Autor:
Claire Marchal, Nivedita Singh, Zachary Batz, Jayshree Advani, Catherine Jaeger, Ximena Corso-Díaz, Anand Swaroop
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The genome-wide high-resolution chromatin contact of the human retina identifies genetic control of cell-type specific gene expression pattern, missing heritability in retinopathies, and candidate genes/variants for diseases including AMD and glaucom
Externí odkaz:
https://doaj.org/article/5b574a6112fd441fa1e95fe4670bb10b
Autor:
Aleksander Tworak, Alexander V. Kolesnikov, John D. Hong, Elliot H. Choi, Jennings C. Luu, Grazyna Palczewska, Zhiqian Dong, Dominik Lewandowski, Matthew J. Brooks, Laura Campello, Anand Swaroop, Philip D. Kiser, Vladimir J. Kefalov, Krzysztof Palczewski
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112982- (2023)
Summary: In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor (RGR) photoisomerase, which is expressed in both the
Externí odkaz:
https://doaj.org/article/d81d281593bd407d80bcbeef11c89b36
Autor:
Ashley A. Farre, Chi Sun, Margaret R. Starostik, Samuel S. Hunter, Milton A. English, Audrey Duncan, Abirami Santhanam, Eyad Shihabeddin, John O’Brien, Anand Swaroop, Deborah L. Stenkamp
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionUnderstanding how photoreceptor genes are regulated is important for investigating retinal development and disease. While much is known about gene regulation in cones, the mechanism by which tandemly-replicated opsins, such as human long
Externí odkaz:
https://doaj.org/article/ec4bd1aa16184a72a815a78e2882bab6