Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

Autor: Benedetta Ubezio, Raquel Agudo Blanco, Ilse Geudens, Fabio Stanchi, Thomas Mathivet, Martin L Jones, Anan Ragab, Katie Bentley, Holger Gerhardt

Publikováno v: eLife, Vol 5 (2016)

Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo

Externí odkaz: https://doaj.org/article/d6ed384d8c4a4d5b868cf2aacd1fd32d

Correction: dynamic endothelial cell rearrangements drive developmental vessel regression.

Autor: Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M Lopes, Aida P Lima, Anan Ragab, Russell T Collins, Li-Kun Phng, Peter V Coveney, Holger Gerhardt

Publikováno v: PLoS Biology, Vol 13, Iss 5, p e1002163 (2015)

[This corrects the article DOI: 10.1371/journal.pbio.1002125.].

Externí odkaz: https://doaj.org/article/8e2b316e4e87403b8eabbbaa558f2835

The chromatin remodelling factor dATRX is involved in heterochromatin formation.

Autor: Andrew R Bassett, Sarah E Cooper, Anan Ragab, Andrew A Travers

Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2099 (2008)

Despite extensive study of heterochromatin, relatively little is known about the mechanisms by which such a structure forms. We show that the Drosophila homologue of the human alpha-thalassemia and mental retardation X-linked protein (dATRX), is impo

Externí odkaz: https://doaj.org/article/a524319c04094e6f9fea2f9ca3242d6c

Actin cortex architecture regulates cell surface tension

Autor: Ewa K. Paluch, Guillaume Salbreux, Philippe P. Roux, Priyamvada Chugh, Kai Dierkes, Matthew B. Smith, Davide A. D. Cassani, Andrew G. Clark, Anan Ragab, Guillaume Charras

Publikováno v: Nature cell biology

Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fb3b9b1d567c3aad8fd11194c7001c
https://pubmed.ncbi.nlm.nih.gov/28530659

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

Autor: Raquel Blanco, Thomas Mathivet, Katie Bentley, Fabio Stanchi, Anan Ragab, Holger Gerhardt, Ilse Geudens, Benedetta Ubezio, Martin L. Jones

Publikováno v: eLife
eLife, Vol 5 (2016)
Ubezio, B, Blanco, R A, Geudens, I, Stanchi, F, Mathivet, T, Jones, M L, Ragab, A, Bentley, K & Gerhardt, H 2016, ' Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion ', eLife, vol. 5, no. APRIL2016, e12167 . https://doi.org/10.7554/eLife.12167

Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84ede18968a83640fa88e8f9709eb61
http://europepmc.org/articles/PMC4894757