Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum

Autor: Pascal Bigey, Catherine Lavazec, Magali Blaud, Laetitia Kermasson, Bernina Naissant, Jose-Juan Lopez-Rubio, Kossiwa Bandje, Gordon Langsley, Philippe Deloron, Murielle Lohezic, Marlène Vayssières, Anais Merckx

Publikováno v: Malaria Journal
Malaria Journal, 2016, 15 (1), pp.248. ⟨10.1186/s12936-016-1275-9⟩
Malaria Journal, BioMed Central, 2016, 15 (1), pp.248. 〈10.1186/s12936-016-1275-9〉
Malaria Journal, BioMed Central, 2016, 15 (1), pp.248. ⟨10.1186/s12936-016-1275-9⟩

International audience; Background: The asexual intra‑erythrocytic multiplication of the malaria parasite Plasmodium falciparum is regulated by various molecular mechanisms. In eukaryotic cells, protein kinases are known to play key roles in cell c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbefe10c4d66b1b25f6ccfcf5a0d55ca
https://www.hal.inserm.fr/inserm-01310216

Anion channels in Plasmodium-falciparum-infected erythrocytes and protein kinase A

Autor: Gordon Langsley, Guillaume Bouyer, Serge L.Y. Thomas, Anais Merckx, Stéphane Egée

Publikováno v: Trends Parasitol
Trends Parasitol, 2009, 25 (3), pp.139-44. ⟨10.1016/j.pt.2008.12.005⟩
Trends Parasitol, 2009, 25 (3), pp.139-44. 〈10.1016/j.pt.2008.12.005〉

International audience; By replicating within red blood cells, malaria parasites are largely hidden from immune recognition; however, in the cells, nutrients are limiting and hazardous metabolic end products can rapidly accumulate. Therefore, to surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a41a8c507ab1423b8f61eb2aa5143b
https://hal.archives-ouvertes.fr/hal-00411298

A Photoalkylative Fluorogenic Probe of Guttiferone A for Live Cell Imaging and Proteome Labeling in Plasmodium falciparum

Autor: Romain Duval, Kevin Cottet, Magali Blaud, Anaïs Merckx, Sandrine Houzé, Philippe Grellier, Marie-Christine Lallemand, Sylvie Michel

Publikováno v: Molecules, Vol 25, Iss 21, p 5139 (2020)

Guttiferone A (GA) 1, a polycyclic polyprenylated acylphloroglucinol (PPAP) isolated from the plant Symphonia globulifera (Clusiaceae), constitutes a novel hit in antimalarial drug discovery. PPAPs do not possess identified biochemical targets in mal

Externí odkaz: https://doaj.org/article/3b13fbe4653946bb8b79b09be9134e8b

[Prevention and treatment of malaria: in vitro evaluation of new compounds]

Autor: Pradines B, Fusai T, Rogier C, Keundjian A, Sinou V, Anais Merckx, Mosnier J, Daries W, Torrentino M, Parzy D

Publikováno v: Europe PubMed Central

One of the current options for reducing the morbidity and mortality of malaria are chemoprophylaxis and chemotherapy. For this reason, the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::670d90f396eaf63d1f888921d02bd315
http://europepmc.org/abstract/med/11787425

Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance.

Autor: Anaïs Merckx, Marie-Paule Nivez, Guillaume Bouyer, Pietro Alano, Gordon Langsley, Kirk Deitsch, Serge Thomas, Christian Doerig, Stéphane Egée

Publikováno v: PLoS Pathogens, Vol 4, Iss 2, p e19 (2008)

Malaria symptoms occur during Plasmodium falciparum development into red blood cells. During this process, the parasites make substantial modifications to the host cell in order to facilitate nutrient uptake and aid in parasite metabolism. One signif

Externí odkaz: https://doaj.org/article/ce02154df4984988a0de2183533caa4d