Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

Autor: Wei Wang, Alla Fane-Dremucheva, Hui Lui, Siobhan O'Leary, Alison Davis, Anneliese O. Speak, Alastair Beasley, Qi Liang, Rocco Sciarrillo, Hanif Ali, Jamie Campbell, Ian Kirby, Miha Kosmac, Sara Chalk, Michael J. Owen, Luke Bayliss, Dominik Spensberger, Richard G. Brown, Laura Tuffery, Glenn Friedrich, E-Chiang Lee, Volker Germaschewski, Tara Bloomfield-Gerdes, Sophie Wells, Allan Bradley, Nikole Waddell, Jemima Paterson, Adam Carpenter, Laura Bonoli, Anais Legent, Nick England, Bettina Franz, Andrew Wood, Vivian Wong, Helen Holmes, Steve Holmes, Anais Manin

Publikováno v: Nature Biotechnology, 32(4), 356-63. Nature Publishing Group
Lee, E-C, Liang, Q, Ali, H, Bayliss, L, Beasley, A, Bloomfield-Gerdes, T, Bonoli, L, Brown, R, Campbell, J, Carpenter, A, Chalk, S, Davis, A, England, N, Fane-Dremucheva, A, Franz, B, Germaschewski, V, Holmes, H, Holmes, S, Kirby, I, Kosmac, M, Legent, A, Lui, H, Manin, A, O'Leary, S, Paterson, J, Sciarrillo, R, Speak, A, Spensberger, D, Tuffery, L, Waddell, N, Wang, W, Wells, S, Wong, V, Wood, A, Owen, M J, Friedrich, G A & Bradley, A 2014, ' Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery ', Nature Biotechnology, vol. 32, no. 4, pp. 356-63 . https://doi.org/10.1038/nbt.2825

If immunized with an antigen of interest, transgenic mice with large portions of unrearranged human immunoglobulin loci can produce fully human antigen-specific antibodies; several such antibodies are in clinical use. However, technical limitations i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2169af16412cbeecfb2d70be70c74d
https://doi.org/10.1038/nbt.2825