Differential association of antioxidative defense genes with white matter integrity in youth bipolar disorder

Autor: Yi Zou, Anahit Grigorian, Kody G. Kennedy, Clement C. Zai, Suyi Shao, James L. Kennedy, Ana C. Andreazza, Stephanie H. Ameis, Chinthaka Heyn, Bradley J. Maclntosh, Benjamin I. Goldstein

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract Oxidative stress is associated with white matter diffusion metrics in adults with bipolar disorder (BD). We examined the association of single-nucleotide polymorphisms in the oxidative stress system, superoxide dismutase-2 (SOD2) rs4880 and

Externí odkaz: https://doaj.org/article/80a09ab6fbd3436f8206783ccc6b69ea

Measuring Brain Temperature in Youth Bipolar Disorder Using a Novel Magnetic Resonance Imaging Approach: A Proof-of-concept Study

Autor: Benjamin I. Goldstein, Yi Zou, Chinthaka Heyn, Anahit Grigorian, Fred Tam, Ana Cristina Andreazza, Simon J. Graham, Bradley J. Maclntosh

Publikováno v: Current Neuropharmacology. 21:1355-1366

Background: There is evidence of alterations in mitochondrial energy metabolism and cerebral blood flow (CBF) in adults and youth with bipolar disorder (BD). Brain thermoregulation is based on the balance of heat-producing metabolism and heat-dissipa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::239f5a867fc48b3f1c211fcf1080c5e0
https://doi.org/10.2174/1570159x21666230322090754

Sex differences in cerebral blood flow among adolescents with bipolar disorder

Autor: Rachel H. B. Mitchell, Anahit Grigorian, Andrew Robertson, Simina Toma, Nicholas J. Luciw, Sudhir Karthikeyan, Henri J. M. M. Mutsaerts, Lisa Fiksenbaum, Arron W. S. Metcalfe, Bradley J. MacIntosh, Benjamin I. Goldstein

Publikováno v: Mitchell, R H B, Grigorian, A, Robertson, A, Toma, S, Luciw, N J, Karthikeyan, S, Mutsaerts, H J M M, Fiksenbaum, L, Metcalfe, A W S, MacIntosh, B J & Goldstein, B I 2023, ' Sex differences in cerebral blood flow among adolescents with bipolar disorder ', Bipolar Disorders . https://doi.org/10.1111/bdi.13326
Bipolar Disorders. Blackwell Munksgaard

Background: Abnormalities in cerebral blood flow (CBF) are common in bipolar disorder (BD). Despite known differences in CBF between healthy adolescent males and females, sex differences in CBF among adolescents with BD have never been studied. Objec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb51172d8eda3de68a2cfe2bf12ed1d6
https://doi.org/10.1111/bdi.13326

Obesity and Cerebral Blood Flow in the Reward Circuitry of Youth With Bipolar Disorder

Autor: Anahit Grigorian, Kody G Kennedy, Nicholas J Luciw, Bradley J MacIntosh, Benjamin I Goldstein

Publikováno v: International Journal of Neuropsychopharmacology. 25:448-456

Background Bipolar disorder (BD) is associated with elevated body mass index (BMI) and increased rates of obesity. Obesity among individuals with BD is associated with more severe course of illness. Motivated by previous research on BD and BMI in you

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1a72a40a9e7593064f729d1c64a538
https://doi.org/10.1093/ijnp/pyac011

Elevated lipids are associated with reduced regional brain structure in youth with bipolar disorder

Autor: Benjamin I. Goldstein, Kody G. Kennedy, Anahit Grigorian, Lisa Fiksenbaum, Brian W. McCrindle, Bradley J. MacIntosh, Rachel H.B. Mitchell, Alvi H. Islam

Publikováno v: Acta Psychiatrica Scandinavica. 143:513-525

Objective Abnormal blood lipid levels are common in bipolar disorder (BD) and correlate with mood symptoms and neurocognition. However, studies have not examined the lipid-brain structure association in BD or youth. Methods This study examined low-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c673de7c173d8a2723fc4ed876586
https://doi.org/10.1111/acps.13278