Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Anahid Jewett"'
Publikováno v:
Vaccines, Vol 12, Iss 6, p 677 (2024)
High-grade serous ovarian cancers (HGSOCs) likely consist of poorly differentiated stem-like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable of completely eradicating PDSLCs, contributing to disease progression
Externí odkaz:
https://doaj.org/article/18104bcbb52e4756a6cd0af6b478e297
Autor:
Jason Chiang, Po-Chun Chen, Janet Pham, Cat-Quynh Nguyen, Kawaljit Kaur, Steven S. Raman, Anahid Jewett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHepatocellular carcinoma (HCC) is the most common primary liver cancer and is the fourth-leading cause of all cancer-related deaths around the world. Liver transplantation, surgery, and local ablation are curative therapies for early-stag
Externí odkaz:
https://doaj.org/article/75c4ceccc37e4e39a684c93647972000
Autor:
Kawaljit Kaur, Anahid Jewett
Publikováno v:
Cells, Vol 13, Iss 3, p 213 (2024)
Our previous studies have introduced osteoclasts (OCs) as major activators of NK cells. It was found that OCs exhibit the capabilities of inducing cell expansion as well as increasing the cytotoxic activity of NK cells by granule release and increasi
Externí odkaz:
https://doaj.org/article/b139cf77cca04c569bbb31a6cf91f300
Autor:
Kawaljit Kaur, Po-Chun Chen, Meng-Wei Ko, Ao Mei, Emanuela Senjor, Subramaniam Malarkannan, Janko Kos, Anahid Jewett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Introduction and methodsIn this study we report that sequential treatment of supercharged NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both poorly differentiated and well differentiated tumors in-vivo in human
Externí odkaz:
https://doaj.org/article/18d8afd694a9415ea920f8f1f438a47b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/66796cbe79854b8cb7a89ba32d9f3af9
Autor:
Barbara Breznik, Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson, Anahid Jewett
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
“Super-charged” NK cells kill patient-derived glioblastoma stem-like cells (GSLCs) in 2D and 3D tumor models, secrete IFN-γ and upregulate the surface expression of CD54 and MHC class I in GSLCs.
Externí odkaz:
https://doaj.org/article/c555a83978a343d1b3e8050a04378dba
Autor:
Kawaljit Kaur, Yujie Sun, Keiichi Kanayama, Kenzo Morinaga, Akishige Hokugo, Ichiro Nishimura, Anahid Jewett
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe potential mechanisms governing drug induced osteonecrosis of the jaw (ONJ) is not well understood, and is one of the objectives of this study. Thus, we tested the release of IFN-γ within different immune compartments including bone m
Externí odkaz:
https://doaj.org/article/0a852aafffd246d69d2a24b08221bb53
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 5, Iss , Pp 100043- (2022)
We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when
Externí odkaz:
https://doaj.org/article/8ae9e5c44bef4621a7e1ea06bb89dbb3
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activation of CD8+ T cells by targe
Externí odkaz:
https://doaj.org/article/e17d77d68b1d4c05bf67756c29ed0972
Autor:
Anahid Jewett, Janko Kos, Kawaljit Kaur, Tahmineh Safaei, Christine Sutanto, Wuyang Chen, Paul Wong, Artin Keshishian Namagerdi, Changge Fang, Yuman Fong, Meng-Wei Ko
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 41-52 (2020)
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and secreted or membrane-bound interferon (IFN)-γ and tumo
Externí odkaz:
https://doaj.org/article/212b71cc55b84369a5a6193c600e4499