Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anaelle A. Dumas"'
Autor:
Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou, Nicola Pomella, Xinyu Zhang, James R. Boot, Tania A. Jones, Thomas O. Millner, Anaelle A. Dumas, Vardhman Rakyan, Jeremy Rees, Jamie L. Thompson, Juho Vuononvirta, Suchita Nadkarni, Tedani El Assan, Natasha Aley, Yung-Yao Lin, Pentao Liu, Sven Nelander, Denise Sheer, Catherine L. R. Merry, Federica Marelli-Berg, Sebastian Brandner, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the disco
Externí odkaz:
https://doaj.org/article/eef727b592d24a7697303fa96e18e608
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.
Externí odkaz:
https://doaj.org/article/bd15556f976d414a8586ab29954b52a8
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/0060757100ba43568e06666c7ec6a7c8
Autor:
James R. Boot, Denise Sheer, Vardhman K. Rakyan, Catherine L.R. Merry, Claire Vinel, Sebastian Brandner, Sven Nelander, Yung-Yao Lin, Suchita Nadkarni, Tedani El Assan, Juho Vuononvirta, Thomas O Millner, Federica M. Marelli-Berg, Myrianni Constantinou, Loredana Guglielmi, Jamie L. Thompson, Xinyu Zhang, Gabriel Rosser, Tania A. Jones, Pentao Liu, Nicola Pomella, Anaelle A. Dumas, Jeremy Rees, Natasha Aley, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develo
Publikováno v:
Neuron. 109:2805-2819
Microglial cells perform a plethora of functions in the central nervous system (CNS), involving them in brain development, maintenance of homeostasis in adulthood, and CNS diseases. Significant technical advancements have prompted the development of
Publikováno v:
Immunity. 54(10)
As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the developing and adult brain during homeostasis and disease. They are aided in their tasks by intricate bidirectional communic
Autor:
Yichen Li, Axel Behrens, Ashirwad Merve, Zeng-Jie Yang, Nicola Pomella, Silvia Marino, Joerg D. Hoeck, Anaelle A. Dumas, Denise Sheer, Xinyu Zhang, Serena Acquati, Arianna Sabò, Jennie N. Jeyapalan, Qianhai Fan, Silvia Vicenzi, Gabriel Rosser
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their formation and only few high fidelity mous
Autor:
Thomas O Millner, Eleni Maniati, Anaelle A. Dumas, Maria Victoria Niklison-Chirou, Jun Wang, Nicola Pomella, Verónica Freire-Benéitez, Pedro R. Cutillas, Vinothini Rajeeve, Silvia Marino
Publikováno v:
NAR Cancer
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Comp
Autor:
Eleni Maniati, Jun Wang, Nicola Pomella, Maria Victoria Niklison-Chirou, Verónica Freire-Benéitez, Thomas O Millner, Silvia Marino, Vinothini Rajeeve, Anaelle A. Dumas, Pedro R. Cutillas
Publikováno v:
NAR Cancer
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Comp
Autor:
Natasha Aley, Anantha Marisetty, Loredana Guglielmi, Sebastian Brandner, Johanna A. Joyce, Denise Sheer, Robert L. Bowman, Nicola Pomella, Jeremy Rees, Silvia Marino, Jun Wei, Amy B. Heimberger, Anaelle A. Dumas, Gabriel Rosser, Thomas O Millner, Claire Vinel
Publikováno v:
The EMBO Journal
The EMBO journal, vol. 39, no. 15, pp. e103790
The EMBO journal, vol. 39, no. 15, pp. e103790
Tumour‐associated microglia/macrophages (TAM) are the most numerous non‐neoplastic populations in the tumour microenvironment in glioblastoma multiforme (GBM), the most common malignant brain tumour in adulthood. The mTOR pathway, an important re