Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anabel Y. Schweitzer"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Technologies that generate precise combinatorial genome modifications are well suited to dissect the polygenic basis of complex phenotypes and engineer synthetic genomes. Genome modifications with engineered nucleases can lead to undesirable
Externí odkaz:
https://doaj.org/article/55dfb881cd854bf78e3bfa44d467b647
Autor:
Emma M Schatoff, Miguel Foronda, Darjus F. Tschaharganeh, Christopher R. Vakoc, Jordana K. Thibado, Teng Han, Sukanya Goswami, Maria Paz Zafra, Francisco J. Sánchez-Rivera, Amber Simon, Scott W. Lowe, Lukas E. Dow, Marco Breinig, Alyna Katti, Emma Montgomery, Junwei Shi, Anabel Y Schweitzer
CRISPR base editing is a potentially powerful technology that enables the creation of genetic mutations with single base pair resolution. By re-engineering both DNA and protein sequences, we developed a collection of constitutive and inducible base e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07af47ec48802ccfe214f79e8cd2798
Autor:
Lukas E. Dow, Alyna Katti, Miguel Foronda, Edward R. Kastenhuber, Marco Breinig, Anabel Y Schweitzer, Teng Han, Junwei Shi, Maria Paz Zafra, Francisco J. Sánchez-Rivera, Amber Simon, Sukanya Goswami, Darjus F. Tschaharganeh, Scott W. Lowe, Emma M Schatoff, Emma Montgomery, Christopher R. Vakoc, Jordana K. Thibado
Publikováno v:
Nature biotechnology
CRISPR base editing enables the creation of targeted single-base conversions without generating double stranded breaks. However, the efficiency of current base editors is very low in many cell types. We re-engineered the sequences of BE3, BE4Gam, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed21963b2b64ff43873380565162b437
https://pubmed.ncbi.nlm.nih.gov/29969439
https://pubmed.ncbi.nlm.nih.gov/29969439