Cancer-Stem-Cell Phenotype-Guided Discovery of a Microbiota-Inspired Synthetic Compound Targeting NPM1 for Leukemia

Autor: Sergio Algar, Henar Vázquez-Villa, Pedro Aguilar-Garrido, Miguel Ángel Navarro-Aguadero, María Velasco-Estévez, Anabel Sánchez-Merino, Iván Arribas-Álvarez, Alberto Paradela, Rafael L. Giner-Arroyo, Joaquín Tamargo-Azpilicueta, Irene Díaz-Moreno, Joaquín Martínez-López, Miguel Gallardo, María L. López-Rodríguez, Bellinda Benhamú

Publikováno v: JACS Au, Vol 4, Iss 5, Pp 1786-1800 (2024)

Externí odkaz: https://doaj.org/article/e7a9f77fa8834205a60b79aaa872ba6b

2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease

Autor: Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de los Frailes, Richard S. Roberts, Juan A. Ballesteros, Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I. Loza, María L. López-Rodríguez

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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Tolerance development caused by dopamine replacement with L-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson’s disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ee8cb90d20910f36acb8e932c24b4d
https://hdl.handle.net/10668/22592

Asymmetric synthesis of polycyclic 3-fluoroalkylproline derivatives by intramolecular azomethine ylide cycloaddition

Autor: Pedro Merino, Carlos del Pozo, Tomás Tejero, Anabel Sánchez-Merino, Daniel Hammerl, Santos Fustero, Fernando Rabasa-Alcañiz

Publikováno v: Organic Chemistry Frontiers
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

The asymmetric synthesis of polycyclic fluorinated proline derivatives has been accomplished by means of an intramolecular azomethine ylide cycloaddition with fluorinated dipolarophiles. Thus, the reaction of benzaldehydes bearing a trifluoromethyl a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4c274691400ca3ab8ffb883363fa91
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3363