Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Ana-Maria Lennon"'
Autor:
Elisa Bonnin, Maria Rodrigo Riestra, Federico Marziali, Rafael Mena Osuna, Jordan Denizeau, Mathieu Maurin, Juan Jose Saez, Mabel Jouve, Pierre-Emmanuel Bonté, Wilfrid Richer, Fabien Nevo, Sebastien Lemoine, Nicolas Girard, Marine Lefevre, Edith Borcoman, Anne Vincent-Salomon, Sylvain Baulande, Helene D. Moreau, Christine Sedlik, Claire Hivroz, Ana-Maria Lennon-Duménil, Jimena Tosello Boari, Eliane Piaggio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Tregs) are plastic cells playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to the microenvironment where they reside; as a consequence, their molecular and functional profiles differ am
Externí odkaz:
https://doaj.org/article/7c63a70c3d6a473080accb289f96f5ea
Autor:
Rémy Char, Zhuangzhuang Liu, Cédric Jacqueline, Marion Davieau, Maria-Graciela Delgado, Clara Soufflet, Mathieu Fallet, Lionel Chasson, Raphael Chapuy, Voahirana Camosseto, Eva Strock, Rejane Rua, Catarina R. Almeida, Bing Su, Ana-Maria Lennon-Duménil, Beatrice Nal, Antoine Roquilly, Yinming Liang, Stéphane Méresse, Evelina Gatti, Philippe Pierre
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 (RUFY3) exists as tw
Externí odkaz:
https://doaj.org/article/4a23f4a1b15044b5bbac175e040f08dd
Autor:
Dorian Obino, Mathieu Maurin, Florent Dingli, Damarys Loew, Aurianne Lescure, Emmanuel Terriac, Christel Goudot, Odile Malbec, Danielle Lankar, Maria-Isabel Yuseff, Ana-Maria Lennon-Duménil, Hélène D. Moreau
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract Cell polarity is an essential and highly conserved process governing cell function. Cell polarization is generally triggered by an external signal that induces the relocation of the centrosome, thus defining the polarity axis of the cell. He
Externí odkaz:
https://doaj.org/article/0ec5949e681b4340802533de0ab3c2c9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The immune system relies on the migratory capacity of its cellular components, which must be mobile in order to defend the host from invading micro-organisms or malignant cells. This applies in particular to immune sentinels from the myeloid lineage,
Externí odkaz:
https://doaj.org/article/eda9c1f869f246d58f8f91313ca71fb4
Autor:
Judith Pineau, Léa Pinon, Olivier Mesdjian, Jacques Fattaccioli, Ana-Maria Lennon Duménil, Paolo Pierobon
Publikováno v:
eLife, Vol 11 (2022)
Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses. While the key roles played by bot
Externí odkaz:
https://doaj.org/article/8567b4f1384a47ec8f801b546e5ad540
Autor:
Anita Kumari, Judith Pineau, Pablo J. Sáez, Mathieu Maurin, Danielle Lankar, Mabel San Roman, Katharina Hennig, Vanessa F. Boura, Raphael Voituriez, Mikael C. I. Karlsson, Martial Balland, Ana-Maria Lennon Dumenil, Paolo Pierobon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protr
Externí odkaz:
https://doaj.org/article/153dc305ef9a4480872d0c78f10b8923
Autor:
Yessia Hidalgo, Sarah Núñez, Maria Jose Fuenzalida, Felipe Flores-Santibáñez, Pablo J. Sáez, Jessica Dorner, Ana-Maria Lennon-Dumenil, Victor Martínez, Emmanuel Zorn, Mario Rosemblatt, Daniela Sauma, Maria Rosa Bono
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B c
Externí odkaz:
https://doaj.org/article/0f41c6a3db1d40fbab671f264b1a1c4a
Autor:
Sophia Maschalidi, Paula Nunes-Hasler, Clarissa R Nascimento, Ignacio Sallent, Valérie Lannoy, Meriem Garfa-Traore, Nicolas Cagnard, Fernando E. Sepulveda, Pablo Vargas, Ana-Maria Lennon-Duménil, Peter van Endert, Thierry Capiod, Nicolas Demaurex, Guillaume Darrasse-Jèze, Bénédicte Manoury
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association o
Externí odkaz:
https://doaj.org/article/3df7bd0b89fc4e89876f33ce40769f73
Autor:
Lucie Barbier, Pablo J. Sáez, Rafaele Attia, Ana-Maria Lennon-Duménil, Ido Lavi, Matthieu Piel, Pablo Vargas
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Upon infection, mature dendritic cells (mDCs) migrate from peripheral tissue to lymph nodes (LNs) to activate T lymphocytes and initiate the adaptive immune response. This fast and tightly regulated process is tuned by different microenvironmental fa
Externí odkaz:
https://doaj.org/article/07ac5afa11bd4b868092bef3a1ce1064
Autor:
Dorian Obino, Luc Fetler, Andrea Soza, Odile Malbec, Juan José Saez, Mariana Labarca, Claudia Oyanadel, Felipe Del Valle Batalla, Nicolas Goles, Aleksandra Chikina, Danielle Lankar, Fabián Segovia-Miranda, Camille Garcia, Thibaut Léger, Alfonso Gonzalez, Marion Espéli, Ana-Maria Lennon-Duménil, Maria-Isabel Yuseff
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3110-3122.e6 (2018)
Summary: Complete activation of B cells relies on their capacity to extract tethered antigens from immune synapses by either exerting mechanical forces or promoting their proteolytic degradation through lysosome secretion. Whether antigen extraction
Externí odkaz:
https://doaj.org/article/cad33fed519b4f1fb48c44bd48bb7a3b