Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ana Virel"'
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112941 (2014)
Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson's disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the disease.
Externí odkaz:
https://doaj.org/article/608d164f3f71482ead51daed06bf11eb
Publikováno v:
Molecular and Cellular Neuroscience. 98:131-139
Parkinson's disease is the second most common neurodegenerative disease caused by degeneration of dopamine neurons in the substantia nigra. The origin and causes of dopamine neurodegeneration in Parkinson's disease are not well understood but oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e5e5d1f1965052f7b1a4351d0128b0
https://doi.org/10.1016/j.mcn.2019.06.003
https://doi.org/10.1016/j.mcn.2019.06.003
Autor:
Ana Virel, Jarkko Johansson, Jan Axelsson, Madelene Ericsson, Rutger Laterveer, Mattias Ögren, Greger Orädd, Susanna Jakobson Mo, Sara af Bjerkén
Publikováno v:
Neuroscience Letters. 770:136420
This study aimed to explore the beneficial effects of the antioxidant N-acetylcysteine (NAC) on the degenerated dopamine system. The short- and long-term regulatory mechanisms of NAC on the 6-OHDA hemiparkinsonian rat model were longitudinally invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b359ddbe7d836a0c2534481609749074
https://doi.org/10.1016/j.neulet.2021.136420
https://doi.org/10.1016/j.neulet.2021.136420
Autor:
Nina Karalija, Ana Virel, Ingrid Strömberg, Anna Barkander, Greg A. Gerhardt, Noelia Pelegrina-Hidalgo, Sara af Bjerkén, Rasmus Stenmark Persson
Publikováno v:
Neurochemistry international. 131
In Parkinson's disease, degeneration of substantia nigra dopaminergic neurons is accompanied by damage on other neuronal systems. A severe denervation is for example seen in the locus coerulean noradrenergic system. Little is known about the relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddce24652e50f156d2a98de8ba02b16
https://pubmed.ncbi.nlm.nih.gov/31542295
https://pubmed.ncbi.nlm.nih.gov/31542295
Autor:
Greger Orädd, Sonia Olmedo-Díaz, Sara af Bjerkén, Ana Virel, Daniel Marcellino, Héctor Estévez-Silva
Publikováno v:
Neuroscience. 362
Brain iron accumulation is a common feature shared by several neurodegenerative disorders including Parkinson's disease. However, what produces this accumulation of iron is still unknown. In this study, the 6-hydroxydopamine (6-OHDA) hemi-parkinsonia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cc165825528ceb027fde060726be54
https://pubmed.ncbi.nlm.nih.gov/28842186
https://pubmed.ncbi.nlm.nih.gov/28842186
Autor:
Ana Virel, Lars Backman
Publikováno v:
Molecular Biology and Evolution. 24:2254-2265
Alpha-actinin is a ubiquitous actin-binding protein, composed of 3 domains; an actin-binding domain and a calcium-binding domain at the termini, connected by a rod domain composed by 1, 2, or 4 spectrin repeats (SRs). To understand how the rod domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fcd0f8be5f9a1be821aecb0e448e75
https://doi.org/10.1093/molbev/msm168
https://doi.org/10.1093/molbev/msm168
Publikováno v:
The European journal of neuroscience. 42(10)
Neuroinflammation is a chronic event in neurodegenerative disorders. In the rat model of Parkinson's disease, including a striatal injection of the neurotoxin 6-hydroxydopamine (6-OHDA), antioxidant treatment affects the inflammatory process. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7111a106e2f0a2b269bbf16ba11493cd
https://pubmed.ncbi.nlm.nih.gov/26273789
https://pubmed.ncbi.nlm.nih.gov/26273789
Autor:
Ana Virel, Lars Backman
Publikováno v:
Molecular and Biochemical Parasitology. 145:11-17
We have cloned, expressed and characterized a alpha-actinin-like protein of Entamoeba histolytica. Analysis of the primary structure reveals that the essential domains of the alpha-actinin protein family are conserved: an N-terminus actin-binding dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2920bbc2e4300c844704ee8cf55421
https://doi.org/10.1016/j.molbiopara.2005.09.003
https://doi.org/10.1016/j.molbiopara.2005.09.003
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e112941 (2014)
PLoS ONE, Vol 9, Iss 11, p e112941 (2014)
Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson’s disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4b0d5d379614b2b2c4f6d1b744137c
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-98441
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-98441
Publikováno v:
Analytical chemistry. 84(5)
By site directed mutagenesis, we have produced recombinant mutants of human and mouse prethrombin-2 which are able to convert themselves autocatalytically into α-thrombin. We also have created a new method to amplify the signal of bioanalytical assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45737fbcd124eacccd1a389d015bf78
https://pubmed.ncbi.nlm.nih.gov/22324776
https://pubmed.ncbi.nlm.nih.gov/22324776