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Autor:
Ana Tufegdžić Vidaković, Ronald C. Conaway, Laura Milligan, Joan W. Conaway, Juston C. Weems, Stefan Boeing, Aengus Stewart, Michelle Harreman, Michelle Neumann, Jesper Q. Svejstrup, Ambrosius P. Snijders, David Tollervey, Richard Mitter, Vesela Encheva, Gavin Kelly, Anna Herlihy, Marta Rodríguez-Martínez, Liam Gaul
Publikováno v:
Cell
Tufegdžić Vidaković, A, Mitter, R, Kelly, G P, Neumann, M, Harreman, M, Rodríguez-Martínez, M, Herlihy, A, Weems, J C, Boeing, S, Encheva, V, Gaul, L, Milligan, L, Tollervey, D, Conaway, R C, Conaway, J W, Snijders, A P, Stewart, A & Svejstrup, J Q 2020, ' Regulation of the RNAPII Pool Is Integral to the DNA Damage Response ', Cell, vol. 180, no. 6, pp. 1245-1261.e21 . https://doi.org/10.1016/j.cell.2020.02.009
Tufegdžić Vidaković, A, Mitter, R, Kelly, G P, Neumann, M, Harreman, M, Rodríguez-Martínez, M, Herlihy, A, Weems, J C, Boeing, S, Encheva, V, Gaul, L, Milligan, L, Tollervey, D, Conaway, R C, Conaway, J W, Snijders, A P, Stewart, A & Svejstrup, J Q 2020, ' Regulation of the RNAPII Pool Is Integral to the DNA Damage Response ', Cell, vol. 180, no. 6, pp. 1245-1261.e21 . https://doi.org/10.1016/j.cell.2020.02.009
Summary In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insi