Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ana Toledano‐Zaragoza"'
Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Autor:
Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N. Mitroi, Rafael Luján, José A. Esteban, María Dolores Ledesma
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-13 (2024)
Abstract Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1nmf164) we show aberrant
Externí odkaz:
https://doaj.org/article/a29dff6528f64981ad437746890a57a7
Autor:
Beatriz Soto-Huelin, Bohdan Babiy, Oscar Pastor, Mario Díaz-García, Ana Toledano-Zaragoza, María Dolores Frutos, Juan Carlos Espín, Francisco A. Tomás-Barberán, Rebeca Busto, María Dolores Ledesma
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106141- (2023)
Niemann Pick diseases types A (NPDA) and C (NPDC) are lysosomal storage disorders (LSDs) leading to cognitive impairment, neurodegeneration, and early death. NPDA and NPDC have different genetic origins, being caused by mutations in the acid sphingom
Externí odkaz:
https://doaj.org/article/41ec54e488d340289457ccc81c47e41e
Autor:
Adrián Bartoll, Ana Toledano‐Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesma
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-20 (2020)
Abstract Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO)
Externí odkaz:
https://doaj.org/article/a07b4ba9bc5b4fa6a8d2a758fb96efdc
Autor:
Gabriel G. Cataldi, Setiembre D. Elorza, Ana Toledano‐Zaragoza, Soledad de Olmos, Andrea B. Cragnolini, Mauricio G. Martín
Publikováno v:
The Journal of comparative neurologyREFERENCES. 531(3)
Cholesterol-24-hydroxylase (CYP46), a member of the cytochrome P450 superfamily of enzymes, is selectively expressed in the brain and is mainly responsible for cholesterol turnover in the central nervous system. Although increased cyp46A1 gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd1b9a75308e439768a294a8bfd5865
https://pubmed.ncbi.nlm.nih.gov/36453552
https://pubmed.ncbi.nlm.nih.gov/36453552
Autor:
Mario Fernández-de Frutos, Virginia Pardo-Marqués, Marta Torrecilla-Parra, Patricia Rada, Ana Pérez-García, Yolanda Martín-Martín, Gema de la Peña, Ana Gómez, Ana Toledano-Zaragoza, Diego Gómez-Coronado, María José Casarejos, José M. Solís, Noemí Rotllan, Óscar Pastor, María Dolores Ledesma, Ángela M. Valverde, Rebeca Busto, Cristina M. Ramírez
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1866:194938
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667259dc451419e9297194b54b7bf664
https://doi.org/10.1016/j.bbagrm.2023.194938
https://doi.org/10.1016/j.bbagrm.2023.194938
Autor:
Edward H. Schuchman, Adrian Bartoll, Maria Dolores Ledesma, Manuel Guzmán, Josefina Casas, Ana Toledano-Zaragoza
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)
EMBO Molecular Medicine
Digital.CSIC. Repositorio Institucional del CSIC
instname
EMBO Molecular Medicine
Digital.CSIC. Repositorio Institucional del CSIC
instname
Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dee8f7d464fb96d93f4de51c6473d04
http://hdl.handle.net/10261/237277
http://hdl.handle.net/10261/237277
Autor:
María Recuero, María J. Bullido, Isabel Sastre, Henrike Kristen, Patricia Llorente, Jesús Aldudo, Ana Toledano-Zaragoza
Publikováno v:
Journal of Alzheimer's Disease. 66:1397-1408
Amyloid-β (Aβ), a major component of senile plaques, is generated via the proteolysis of amyloid-β protein precursor (AβPP). This cleavage also produces AβPP fragment-derived oligomers which can be highly neurotoxic. AβPP metabolism/processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded973346511359e4d57cca1ccc2c4d7
https://doi.org/10.3233/jad-170159
https://doi.org/10.3233/jad-170159
Publikováno v:
Neuropharmacology. 171:107851
Most lysosomal storage disorders (LSDs) cause progressive neurodegeneration leading to early death. While the genetic defects that cause these disorders impact all cells of the body, neurons are particularly affected. This vulnerability may be explai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbc3e72c725b9a3f53be0a293061652
https://doi.org/10.1016/j.neuropharm.2019.107851
https://doi.org/10.1016/j.neuropharm.2019.107851