Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review

Autor: Alcina Frederica Nicol, Ana Teresa Gomes Fernandes, Maria da Gloria Bonecini-Almeida

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 100, Iss 1, Pp 1-12 (2005)

Human immunodeficiency virus (HIV-1) has become an important risk factor for human papillomavirus (HPV) infection and the development of HPV associated lesions in the female genital tract. HIV-1 may also increase the oncogenicity of high risk HPV typ

Externí odkaz: https://doaj.org/article/df18f3945bde42c9947be3f3851c141f

TNFR1 single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulate in situ cervical TNFR1 expression

Autor: Natália Pereira da Rocha, Evandro Mendes Klumb, Elyzabeth Avvad-Portari, Ana Teresa Gomes Fernandes, Eric Henrique Roma, Amanda Chaves Pinto, Fabio Russomano, Maria da Gloria Bonecini-Almeida, Jacyara Maria Brito Macedo

Publikováno v: Oncotarget

TNF-α is involved in HPV infection control by triggering cell signaling through binding in specific receptors TNFR1 and TNFR2. Genetic polymorphisms in these receptors may influence TNF-α signaling. Herein, we investigated TNFR1 rs767455 and rs2234

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9656bb410fd382e439dad57f3905c9
http://europepmc.org/articles/PMC6398171

Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia

Autor: Ruth Khalili Friedman, B. Grinsztejn, Jacyara Maria Brito Macedo, Fabio Russomano, Ana Teresa Gomes Fernandes, Otoniel Martinez-Maza, Elena Vendrame, Evandro Mendes Klumb, Amanda Chaves Pinto, Natalia Pereira da Rocha, Maria da Gloria Bonecini-Almeida, Elyzabeth Avvad

Publikováno v: Apoptosis. 20:1347-1357

HPV is associated with cervical cancer and plays a crucial role in tumor formation. Apoptosis is regulated by different pathways involving genes that either promote (BCL2 gene) or inhibit (BAX gene) cell death. Our goal was to determine whether the B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a0a31c5768f59168fb3448331fc971
https://doi.org/10.1007/s10495-015-1156-7

Balance of apoptotic and anti-apoptotic marker and perforin granule release in squamous intraepithelial lesions. HIV infection leads to a decrease in perforin degranulation

Autor: Aparecida Tristão, Maria da Gloria Bonecini-Almeida, B. Grinsztejn, Elyzabeth Avvad, Fabio Russomano, Marcel de Souza Borges Quintana, Natalia Pereira da Rocha, Ana Teresa Gomes Fernandes, Maurício de Andrade Pérez, Fátima Conceição-Silva

Publikováno v: Experimental and molecular pathology. 95(2)

Cell-mediated cytotoxicity plays an important role in the regulation to HPV-associated cervical intraepithelial neoplasia. HIV co-infection is related to poorer prognosis and more rapid clinical progression to cancer. We evaluated the presence of cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045a3b703295af0f6f9e602cba2c9aca
https://pubmed.ncbi.nlm.nih.gov/23791892

Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection -- review

Autor: Ana Teresa Gomes Fernandes, Maria da Gloria Bonecini-Almeida, Alcina F. Nicol

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 100, Iss 1, Pp 1-12 (2005)
Memórias do Instituto Oswaldo Cruz, Volume: 100, Issue: 1, Pages: 1-12, Published: FEB 2005

Human immunodeficiency virus (HIV-1) has become an important risk factor for human papillomavirus (HPV) infection and the development of HPV associated lesions in the female genital tract. HIV-1 may also increase the oncogenicity of high risk HPV typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89cd7c0c530eb523a3520de2a949c2
https://pubmed.ncbi.nlm.nih.gov/15867955