Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ana Tapia-Abellán"'
Autor:
Cristina Molina-López, Laura Hurtado-Navarro, Carlos J. García, Diego Angosto-Bazarra, Fernando Vallejo, Ana Tapia-Abellán, Joana R. Marques-Soares, Carmen Vargas, Segundo Bujan-Rivas, Francisco A. Tomás-Barberán, Juan I. Arostegui, Pablo Pelegrin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory condition resulting from monoallelic NLRP3 variants that facilitate IL-1β production. Although these are gain-of-function variants characterized by hypersensitivity to cel
Externí odkaz:
https://doaj.org/article/8fff75ee7c594dc3a2b4f18e746c4a0b
Autor:
Iva Hafner-Bratkovič, Petra Sušjan, Duško Lainšček, Ana Tapia-Abellán, Kosta Cerović, Lucija Kadunc, Diego Angosto-Bazarra, Pablo Pelegrin, Roman Jerala
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Activation of the NLRP3 inflammasome is associated with various diseases but its activation mechanism is not fully understood. Here, the authors determine the impact of different NLRP3 domains on sensing NLRP3 triggers, inflammasome assembly and regu
Externí odkaz:
https://doaj.org/article/1ef3edb735df4712b0a5732ea7fa1100
Autor:
Alexander N R Weber, Ana Tapia-Abellán, Xiao Liu, Sabine Dickhöfer, Juan I Aróstegui, Pablo Pelegrín, Tatjana Welzel, Jasmin B Kuemmerle-Deschner
Publikováno v:
Rheumatology. 61:e299-e313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5be6d452fd737da5cd2565264549fe4
https://doi.org/10.1093/rheumatology/keac273
https://doi.org/10.1093/rheumatology/keac273
Autor:
Alexander N R Weber, Ana Tapia-Abellán, Xiao Liu, Juan I Aróstegui, Pablo Pelegrín, Tatjana Welzel, Jasmin B Kuemmerle-Deschner
Publikováno v:
Rheumatology. 62:e168-e169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabb20f0e0efa67c0891d4800c1801fb
https://doi.org/10.1093/rheumatology/keac718
https://doi.org/10.1093/rheumatology/keac718
Autor:
Pablo Pelegrín, María Tristán-Manzano, Antonio J. Ruiz-Alcaraz, María Martínez-Esparza, Violeta Carmona-Martínez, Pilar Marín-Sánchez, Ana Tapia-Abellán, Francisco Machado-Linde, Miguel Angel Iniesta-Albadalejo, Pilar García-Peñarrubia, Helios Martínez-Banaclocha
Publikováno v:
Immunology & Cell Biology. 98:114-126
Macrophages play an important role in the inflammatory response. Their various biological functions are induced by different membrane receptors, including Toll-like receptors, which trigger several intracellular signaling cascades and activate the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6080cca5f34abc3eb7ca576d57b5ee43
https://doi.org/10.1111/imcb.12305
https://doi.org/10.1111/imcb.12305
Autor:
Horacio Pérez-Sánchez, Pablo Pelegrín, Helios Martínez-Banaclocha, José P. Cerón-Carrasco, Ana Tapia-Abellán, Carlos de Torre-Minguela, Diego Angosto-Bazarra, Juan I. Aróstegui
Publikováno v:
Nature chemical biology
NLRP3 is an innate immune sensor contributing to the development of different diseases including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer’s disease. The molecule sulfonylurea MCC950 is a NLRP3 inflammasome inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d569d6f491b0251870445c4e4d8907b7
https://pubmed.ncbi.nlm.nih.gov/31086329
https://pubmed.ncbi.nlm.nih.gov/31086329
Autor:
Zsofia Bittner, Ana Tapia-Abellán, Alexander N.R. Weber, Tengchuan Jin, Tzu-Hsuan Chang, Xiao Liu, Sangeetha Shankar
Publikováno v:
Journal of Cell Science. 133
The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a fascinating cellular machinery endowed with the capacity for rapid proteolytic processing of the pro-inflammatory cytokine IL-1β and the cell death effector gasdermin D (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c360d6ec4b26d130b56e64b9e1e84b9
https://doi.org/10.1242/jcs.248344
https://doi.org/10.1242/jcs.248344
Autor:
Sabine Dickhöfer, Oliver Hantschel, Hubert Kalbacher, Anita Delor, Franziska Herster, Jasmin Kümmerle-Deschner, Bodo Grimbacher, Carsten L. Greve, Xiao Liu, Ana Marcu, Samuel Wagner, Hao Wu, Liudmila Andreeva, Ana Tapia-Abellán, Yamel Cardona Gloria, Alexander N.R. Weber, Marta Lovotti, Eicke Latz, Michael Scharl, Markus W. Löffler, Maria Mateo Tortola, Olaf-Oliver Wolz, Nadine A. Schilling, Peter Düwell, Matthew Mangan, Sangeetha Shankar, Tzu-Hsuan Chang, Zsofia Bittner, Stefan Stevanovic, Karlotta Bosch, Francesca Bork, Marianne R. Spalinger
Publikováno v:
Journal of experimental medicine 218(11), e20201656 (2021). doi:10.1084/jem.20201656
Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that a well-establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3608b1034f01b278a87ae7f4c5f83cb4
https://pubmed.ncbi.nlm.nih.gov/34554188
https://pubmed.ncbi.nlm.nih.gov/34554188
Autor:
Compan, Baños Mc, Gómez-Sánchez Ai, Pablo Pelegrín, Ana Tapia-Abellán, Florian I. Schmidt, Fátima Martín-Sánchez
Publikováno v:
bioRxiv
Signaling through the inflammasome is important for the inflammatory response. Low concentrations of intracellular K+ are associated with the specific oligomerization and activation of the NLRP3 inflammasome, a type of inflammasome involved in steril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59a4ae32b7cdfb42af9ab59e4fd22f1
Autor:
Jasmin Kümmerle-Deschner, Peter Düwell, Matthew Mangan, Ana Marcu, Olaf-Oliver Wolz, Ana Tapia-Abellán, Franziska Herster, Sangeetha Shankar, Hao Wu, Sabine Dickhöfer, Marta Lovotti, Anita Delor, Samuel Wagner, Liudmila Andreeva, Eicke Latz, Hubert Kalbacher, Markus W. Löffler, Bodo Grimbacher, Zsofia Bittner, Alexander N.R. Weber, Xiao Liu, Karlotta Bosch, Nadine A. Schilling, Stefan Stevanovic
Activity of the NLRP3 inflammasome, a critical mediator of inflammation (1), is controlled by accessory proteins (2, 3), post-translational modifications (4, 5), cellular localization (6, 7) and oligomerization (8). How these factors relate, is uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750f84b4b4fe9a704faa78e0a1d51e60
https://doi.org/10.1101/864702
https://doi.org/10.1101/864702