The chloroplast protein HCF164 is predicted to be associated with Coffea SH9 resistance factor against Hemileia vastatrix

Autor: Leonor Guerra-Guimarães, Carla Pinheiro, Ana Sofia F. Oliveira, Andrea Mira-Jover, Javier Valverde, Fernanda A. de F. Guedes, Herlander Azevedo, Vitor Várzea, Antonio Jesús Muñoz Pajares

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract To explore the connection between chloroplast and coffee resistance factors, designated as SH1 to SH9, whole genomic DNA of 42 coffee genotypes was sequenced, and entire chloroplast genomes were de novo assembled. The chloroplast phylogeneti

Externí odkaz: https://doaj.org/article/221df03167b94ce48445932b3a2442b3

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

Autor: Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider

Publikováno v: eLife, Vol 10 (2021)

Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and co

Externí odkaz: https://doaj.org/article/7aac1beac51a40888c31f6d01e330204

A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors

Autor: Timothy Gallagher, Cecilia Gotti, Ana Sofia F Oliveira, Beatriz Elizabeth Nielsen, Richard B. Sessions, Isabel Bermudez, Adrian J. Mulholland, Teresa Minguez-Viñas, Cecilia Bouzat, Deborah K. Shoemark, Susan Wonnacott

Publikováno v: Minguez-Viñas, T, Nielsen, B E, Shoemark, D K, Gotti, C, Sessions, R B, Mulholland, A J, Bouzat, C, Wonnacott, S, Gallagher, T, Bermudez, I & Oliveira, A S 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389
Minguez Viñas, T, Shoemark, D K, Sessions, R B, Mulholland, A J, Gallagher, T, Oliveira, A S & al., E 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389

Background and PurposeThe α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49465823bbfc1af3116cfe62a1b97773
https://doi.org/10.1111/bph.15389

A General Mechanism for Signal Propagation in the Nicotinic Acetylcholine Receptor Family

Autor: Christopher J. Woods, Timothy Gallagher, Susan Wonnacott, Giovanni Ciccotti, Richard B. Sessions, Ana Sofia F Oliveira, Phil Bates, Adrian J. Mulholland, Christopher J. Edsall, Isabel Bermudez, Gerardo Viedma Nunez

Publikováno v: Oliveira, A S F, Edsall, C J, Woods, C J, Bates, P, Nunez, G V, Wonnacott, S, Bermudez, I, Ciccotti, G, Gallagher, T, Sessions, R B & Mulholland, A J 2019, ' A General Mechanism for Signal Propagation in the Nicotinic Acetylcholine Receptor Family ', Journal of the American Chemical Society, vol. 141, no. 51, 51, pp. 19953-19958 . https://doi.org/10.1021/jacs.9b09055

Nicotinic acetylcholine receptors (nAChRs) modulate synaptic activity in the central nervous system. The α7 subtype, in particular, has attracted considerable interest in drug discovery as a target for several conditions, including Alzheimer's disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e409721e0554bddf3ef1c857441b86d
https://doi.org/10.1021/jacs.9b09055

The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour

Autor: Amaurys Avila Ibarra, Andrew D. Davidson, Deborah K. Shoemark, Ana Sofia F Oliveira, Adrian J. Mulholland, Christiane Schaffitzel, Imre Berger

Publikováno v: Computational and Structural Biotechnology Journal
Oliveira, A, Shoemark, D K, Avila Ibarra, A, Davidson, A D, Berger, I, Berger-Schaffitzel, C H & Mulholland, A J 2021, ' The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour ', Computational and Structural Biotechnology Journal, vol. 20, pp. 139-147 . https://doi.org/10.1101/2021.06.07.447341, https://doi.org/10.1016/j.csbj.2021.12.011
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 139-147 (2022)

Graphical abstract
The SARS-CoV-2 spike protein is the first contact point between the SARS-CoV-2 virus and host cells and mediates membrane fusion. Recently, a fatty acid binding site was identified in the spike (Toelzer et al. Science 2020). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fe15b2963c9d98565174fd7adcac3c
https://pubmed.ncbi.nlm.nih.gov/34934478