Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Ana Saavedra"'
Publikováno v:
BMC Primary Care, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background The COVID-19 pandemic changed the healthcare system, leading to the rapid evolution and implementation of telemedicine (TM). TM has the potential to improve the quality of primary health care and increase accessibility for the pop
Externí odkaz:
https://doaj.org/article/4a81dcaf179348ba89b29f41a79d138b
Publikováno v:
Acta Médica Portuguesa, Vol 33, Iss 3 (2020)
Cerca de 28% dos doentes com dislipidemia apresentam na sua etiologia causas secundárias. A resolução de algumas destas causas pode levar à correção total da dislipidemia. Descreve-se o caso de uma doente do sexo feminino, 50 anos, com obesidad
Externí odkaz:
https://doaj.org/article/230960152d0548798e2a4ba61c1ab83c
Autor:
Margarida Barbosa, Ana Saavedra, Sofia Oliveira, Ligia Reis, Filipa Rodrigues, Milton Severo, Reinhard Sittl, Christoph Maier, Davide M. Carvalho
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Aims: To evaluate (1) the prevalence of diabetic distal symmetrical sensory–motor polyneuropathy (DSPN) and painful DSPN among patients with type 1 diabetes mellitus (DM1) aged over 18 years and (2) the determinant factors of neuropathy and pain in
Externí odkaz:
https://doaj.org/article/d357b0a5f705424aba58030c9e508f03
Autor:
Gloria Blázquez, Anna Castañé, Ana Saavedra, Mercè Masana, Jordi Alberch, Esther Pérez-Navarro
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2019)
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a neural-specific protein that opposes the development of synaptic strengthening and whose levels are altered in several neurodegenerative and psychiatric disorders. Since STEP is expressed in
Externí odkaz:
https://doaj.org/article/640dcb31855a41298c6d5cd62fccbbfc
Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease
Autor:
Shiraz Tyebji, Ana Saavedra, Paula M. Canas, Anna Pliassova, José M. Delgado-García, Jordi Alberch, Rodrigo A. Cunha, Agnès Gruart, Esther Pérez-Navarro
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 41-57 (2015)
Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechanisms, PKA activity is increased in the hippocampus
Externí odkaz:
https://doaj.org/article/ef6f5f933eed4929acfdd4a83b353a0c
Autor:
Eva Lau, Cintia Correia, Paula Freitas, Claúdia Nogueira, Maria Costa, Ana Saavedra, Carla Costa, Davide Carvalho, Manuel Fontoura
Publikováno v:
Archives of Endocrinology and Metabolism, Vol 59, Iss 6, Pp 559-561 (2015)
Permanent neonatal diabetes (PNDM) can result from activating heterozygous mutations in KCNJ11 gene, encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channels (KATP). Sulfonylureas promote KATP closure and stimulate insulin secre
Externí odkaz:
https://doaj.org/article/af04a06c1058458182aad664ae345554
Autor:
Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 3, Pp 461-469 (2009)
Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to excitot
Externí odkaz:
https://doaj.org/article/ecc481ee56a54ab2a61ee8872810af8f
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 1, Pp 92-104 (2007)
We recently proposed the involvement of diffusible modulators in signalling astrocytes to increase glial cell line-derived neurotrophic factor (GDNF) expression after selective dopaminergic injury by H2O2 or l-DOPA. Here we report that interleukin-1
Externí odkaz:
https://doaj.org/article/cb2f5e4bedc84ee49c28d623bf38a2e9
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 3, Pp 533-542 (2006)
The effect of selective injury to dopaminergic neurons on the expression of glial cell line-derived neurotrophic factor (GDNF) was examined in substantia nigra cell cultures. H2O2, mimicking increased oxidative stress, or l-DOPA, the main symptomatic
Externí odkaz:
https://doaj.org/article/61514a6d9ed84d1cb774799d3174c5f8
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73664 (2013)
Huntington's disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide synthase/3',5'-cyclic guanosine monophosphate (nNOS/cGMP) pathway is implicated in synaptic pla
Externí odkaz:
https://doaj.org/article/311e83defce544a292da3c052160b3be