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T-cell Activating Tribodies as a Novel Approach for Efficient Killing of ErbB2-positive Cancer Cells
Autor:
Gennaro Riccio, Valentina Rubino, Margherita Passariello, Ana Rita Da Fonseca Ricardo, Claudia De Lorenzo, Kathy Saraiva, Nico Mertens, Philip Cunnah
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 42(1)
The Tyrosine Kinase Receptor ErbB2 (HER2) when overexpressed in breast cancer (BC) is associated with poor prognosis. The monoclonal antibody Trastuzumab has become a standard treatment of ErbB2+BC. The antibody treatment has limited efficacy, often