Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Ana Rey-Rico"'
Autor:
Natalia Carballo-Pedrares, Federica Ponti, Junquera Lopez-Seijas, Diego Miranda-Balbuena, Nina Bono, Gabriele Candiani, Ana Rey-Rico
Publikováno v:
Journal of Biological Engineering, Vol 17, Iss 1, Pp 1-24 (2023)
Abstract In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage multipotency, proliferative properties, and potent immunomodulatory e
Externí odkaz:
https://doaj.org/article/582209cbf051467d962044db6785e447
Autor:
Junquera López-Seijas, Diego Miranda-Balbuena, Alba Iglesias-Fente, Marta Sacristán-Santos, Natalia Carballo-Pedrares, María C. Arufe, Ana Rey-Rico, Juan Fafián-Labora
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 302-317 (2023)
Senescence is a process characterized by a prolonged irreversible cell-cycle arrest. The accumulation of senescent cells in tissues is related to aging and to the development of age-related diseases. Recently, gene therapy has emerged as a powerful t
Externí odkaz:
https://doaj.org/article/b6c4196608cc44c4a45f2d2b4b9cc5e7
Autor:
Natalia Carballo-Pedrares, Clara Sanjurjo-Rodriguez, Jose Señarís, Silvia Díaz-Prado, Ana Rey-Rico
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2327 (2022)
Gene transfer to mesenchymal stem cells constitutes a powerful approach to promote their differentiation into the appropriate cartilage phenotype. Although viral vectors represent gold standard vehicles, because of their high efficiency, their use is
Externí odkaz:
https://doaj.org/article/1cea0cee6f7f4c189d58532e23611531
Autor:
Jagadeesh K. Venkatesan, Janina Frisch, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini
Publikováno v:
Journal of Experimental Orthopaedics, Vol 4, Iss 1, Pp 1-13 (2017)
Abstract Background Evaluation of gene-based approaches to target human bone marrow aspirates in conditions of mechanical stimulation that aim at reproducing the natural joint environment may allow to develop improved treatments for articular cartila
Externí odkaz:
https://doaj.org/article/2cd077524df04c79a6942220548c9f8a
Autor:
Henning Madry, Jagadeesh Kumar Venkatesan, Natalia Carballo-Pedrares, Ana Rey-Rico, Magali Cucchiarini
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 930 (2020)
Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has recently emerged as an attractive therapeutic
Externí odkaz:
https://doaj.org/article/6eaf9d18477648c5b24798f55427c4ca
Publikováno v:
Pharmaceutics, Vol 12, Iss 8, p 752 (2020)
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimal
Externí odkaz:
https://doaj.org/article/b10b50be350f4923bb7bf0cdaa18a35f
Publikováno v:
Nanomaterials, Vol 10, Iss 6, p 1238 (2020)
Osteoarthritis (OA) is a prevalent joint disease linked to the irreversible degradation of key extracellular cartilage matrix (ECM) components (proteoglycans, type-II collagen) by proteolytic enzymes due to an impaired tissue homeostasis, with the cr
Externí odkaz:
https://doaj.org/article/758dd1508326420c859140c47a79a595
Autor:
Weikun Meng, Ana Rey-Rico, Mickaël Claudel, Gertrud Schmitt, Susanne Speicher-Mentges, Françoise Pons, Luc Lebeau, Jagadeesh K. Venkatesan, Magali Cucchiarini
Publikováno v:
Nanomaterials, Vol 10, Iss 5, p 855 (2020)
Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility and benefits of providing highly chondrorep
Externí odkaz:
https://doaj.org/article/237310a22faf4964890d90622f337fce
Autor:
Fernando Alvarez-Rivera, Ana Rey-Rico, Jagadeesh K Venkatesan, Luis Diaz-Gomez, Magali Cucchiarini, Angel Concheiro, Carmen Alvarez-Lorenzo
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 335 (2020)
As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of viral vectors (recombinant adeno-associated
Externí odkaz:
https://doaj.org/article/17f397af89f244a2be65cab9bf0fd1a3
Autor:
Jagadeesh K. Venkatesan, Weikun Meng, Ana Rey-Rico, Gertrud Schmitt, Susanne Speicher-Mentges, Céline Falentin-Daudré, Amélie Leroux, Henning Madry, Véronique Migonney, Magali Cucchiarini
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 280 (2020)
Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while protecting the cargos from detrimental immun
Externí odkaz:
https://doaj.org/article/ba2b701ca7614da384637281e02ad022