Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Ana R. Jesus"'
1
Akademický článek
Using dicationic ionic liquids to upgrade the cytotoxicity and solubility of poorly water-soluble drugs
Autor: Ana B.P. Silva, Ana R. Jesus, Daniela A.S. Agostinho, José M.S.S. Esperança, Alexandre Paiva, Ana R.C. Duarte, Patrícia M. Reis
Publikováno v: Journal of Ionic Liquids, Vol 3, Iss 1, Pp 100052- (2023)
New dicationic ionic liquids (DcILs) based on carboxylic acid-derived, N-acetyl amino acid-derived or bromide anions, and ammonium cations were synthesized and characterized. DcILs were employed as co-solvents to improve the solubility of ibuprofen a
Externí odkaz: https://doaj.org/article/490fbcfabdd1440fab399237c0b20344
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2
Akademický článek
Ionic Levothyroxine Formulations: Synthesis, Bioavailability, and Cytotoxicity Studies
Autor: António Barreira, Andreia F. M. Santos, Madalena Dionísio, Ana R. Jesus, Ana Rita C. Duarte, Željko Petrovski, Ana B. Paninho, Márcia G. Ventura, Luis C. Branco
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 10, p 8822 (2023)
Thyroid diseases affect a considerable portion of the population, with hypothyroidism being one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to treat hypothyroidism and suppress thyroid stimulating hormone sec
Externí odkaz: https://doaj.org/article/32d7c830f552482286694a93c2a7bcc6
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3
Akademický článek
New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs
Autor: Ana R. Jesus, Luís R. Raposo, Mário R. C. Soromenho, Daniela A. S. Agostinho, José M. S. S. Esperança, Pedro V. Baptista, Alexandra R. Fernandes, Patrícia M. Reis
Publikováno v: Symmetry, Vol 13, Iss 11, p 2053 (2021)
In this work, we prepared new biocompatible N-alkyl cholinium-based ionic liquids to be used as cosolvents to improve the solubility of poorly water-soluble drugs, namely, sodium diclofenac and paracetamol. In this set of ionic liquids, we intend to
Externí odkaz: https://doaj.org/article/1f474b25575d413897627969fb2c2cb5
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4
Improvement of New Dianionic Ionic Liquids vs Monoanionic in Solubility of Poorly Water-Soluble Drugs
Autor: Patrícia M. Reis, José M. S. S. Esperança, Ana B.P. Silva, Ana R. Jesus, Alexandre Paiva, Ana Rita C. Duarte, Daniela A.S. Agostinho
Publikováno v: Journal of Pharmaceutical Sciences. 110:2489-2500
New ionic liquids (ILs) based on dianionic phosphonate anions and ammonium cations were prepared and characterized. They were used as excipients to increase the water solubility of two oral drugs, piroxicam and ibuprofen, that are slightly soluble in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb43a1972b9eac0820f2ad535123382
https://doi.org/10.1016/j.xphs.2021.01.014
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7
Supercritical CO2 Assisted Impregnation of Ibuprofen on Medium-Chain-Length Polyhydroxyalkanoates (mcl-PHA)
Autor: Rita Craveiro, Filomena Freitas, Liane Meneses, Ana R. Jesus, Alexandre Paiva, Maria A.M. Reis
Publikováno v: Molecules
Volume 26
Issue 16
Molecules, Vol 26, Iss 4772, p 4772 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
In this work, we propose the utilization of scCO2 to impregnate ibuprofen into the mcl-PHA matrix produced by Pseudomonas chlororaphis subs. aurantiaca (DSM 19603). The biopolymer has adhesive properties, is biocompatible and has a melting temperatur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55a7946e173d2f6cf47502d04083578
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8
Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids
Autor: Patrícia M. Reis, Luís Raposo, José M. S. S. Esperança, Mário R. C. Soromenho, Alexandra R. Fernandes, Ana R. Jesus, Pedro V. Baptista
Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 137:227-232
The major challenge of the pharmaceutical industry is to find potential solvents for poorly water-soluble drug molecules. Ionic liquids (ILs) have attracted this industry as (co-) solvents due to their unique physicochemical and biological properties
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94f3e4a206721b62e44aed962e05ae4
https://doi.org/10.1016/j.ejpb.2019.03.004
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9
Natural deep eutectic systems, an emerging class of cryoprotectant agents
Autor: Alexandre Paiva, Ana Rita C. Duarte, Liane Meneses, Ana R. Jesus
Publikováno v: Cryobiology
This work aimed at evaluating the potential of using natural deep eutectic systems (NADES) as cryoprotectant agents (CPAs). Several combinations between natural primary metabolites that have been identified in animals that live in extreme cold climat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ae00d2c1989ace227fec8eca2c5f57
https://pubmed.ncbi.nlm.nih.gov/33974836
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10
Natural deep eutectic systems—A new era of cryopreservation
Autor: Ana Rita C. Duarte, Ana R. Jesus, Liane Meneses, Alexandre Paiva
Publikováno v: Eutectic Solvents and Stress in Plants ISBN: 9780128216910
Human and animal cells are extremely important for research and many medical applications; however, they do not survive long-term storage with simple cooling or freezing. On the other hand, the increase in world's population along with the changes in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b700dcba05944863565a899ae45d5375
https://doi.org/10.1016/bs.abr.2020.09.015
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