Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ana R. Georgian"'
Autor:
Gayathri N Sekhar, Ana R Georgian, Lisa Sanderson, Gema Vizcay-Barrena, Rachel C Brown, Paula Muresan, Roland A Fleck, Sarah A Thomas
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173474 (2017)
Pentamidine is an effective trypanocidal drug used against stage 1 Human African Trypanosomiasis (HAT). At the blood-brain barrier (BBB), it accumulates inside the endothelial cells but has limited entry into the brain. This study examined transporte
Externí odkaz:
https://doaj.org/article/28e9a686342e4da29a0188fb884b4905
Autor:
Charles Turner, Luke Wainwright, Jane E. Preston, Simon J R Heales, R Neil Dalton, N. Joan Abbott, Ana R. Georgian, Iain P. Hargreaves
Publikováno v:
Journal of Clinical Medicine
Volume 9
Issue 10
Journal of Clinical Medicine, Vol 9, Iss 3236, p 3236 (2020)
Volume 9
Issue 10
Journal of Clinical Medicine, Vol 9, Iss 3236, p 3236 (2020)
Primary coenzyme Q10 (CoQ10) deficiency is unique among mitochondrial respiratory chain disorders in that it is potentially treatable if high-dose CoQ10 supplements are given in the early stages of the disease.While supplements improve peripheral abn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfe025687dad367a2d764c12a322796
Autor:
Wendy Butcher, Lyn M. O'Brien, F. Javier Salguero, E. Diane Williamson, Francesca Modino, Stuart Woods, Ana R. Georgian, Craig W. Roberts, Jane E. Preston, N. Joan Abbott, Riccardo V. D'Elia
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 324
The field of brain drug delivery faces many challenges that hinder development and testing of novel therapies for clinically important central nervous system disorders. Chief among them is how to deliver large biologics across the highly restrictive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0884c9de956f00202bbc5fba44381bd1
https://pubmed.ncbi.nlm.nih.gov/32512014
https://pubmed.ncbi.nlm.nih.gov/32512014
Autor:
Andrea E. Tóth, Simone S. E. Nielsen, Morten Nielsen, Piotr Siupka, Ana R. Georgian, Siti R. Yusof, Jane E. Preston, Joan Abbott
Publikováno v:
Journal of Visualized Experiments.
The aim of this protocol presents an optimized procedure for the purification and cultivation of pBECs and to establish in vitro blood-brain barrier (BBB) models based on pBECs in mono-culture (MC), MC with astrocyte-conditioned medium (ACM), and non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a112a972b5318397cf7dff7337af5a8
https://doi.org/10.3791/56277
https://doi.org/10.3791/56277
Autor:
Ana R. Georgian, Jane E. Preston, Patrizia Ferretti, Pär G. Engström, Ding Yu, Ahmed M.O. Elbatsh, Sabine Gogolok, N. Joan Abbott, Stefan H. Stricker, Kin Pong U, Christine Ender, Austin Smith, Patrick J. Paddison, Steven M. Pollard, Sladjana Gagrica, Kevin Harvey, Davide Danovi, Paul Bertone, Amos Folarin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e77053 (2013)
Danovi, D, Folarin, A, Gogolok, S, Ender, C, Elbatsh, A M O, Engström, P G, Stricker, S H, Gagrica, S, Georgian, A, Yu, D, U, K P, Harvey, K J, Ferretti, P, Paddison, P J, Preston, J E, Abbott, N J, Bertone, P, Smith, A & Pollard, S M 2013, ' A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 ', PLoS ONE, vol. 8, no. 10, pp. e77053 . https://doi.org/10.1371/journal.pone.0077053
Danovi, D, Folarin, A, Gogolok, S, Ender, C, Elbatsh, A M O, Engström, P G, Stricker, S H, Gagrica, S, Georgian, A, Yu, D, U, K P, Harvey, K J, Ferretti, P, Paddison, P J, Preston, J, Abbott, N J, Bertone, P, Smith, A & Pollard, S M 2013, ' A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 ', PL o S One, vol. 8, no. 10, e77053 . https://doi.org/10.1371/journal.pone.0077053
PLoS ONE, Vol 8, Iss 10, p e77053 (2013)
Danovi, D, Folarin, A, Gogolok, S, Ender, C, Elbatsh, A M O, Engström, P G, Stricker, S H, Gagrica, S, Georgian, A, Yu, D, U, K P, Harvey, K J, Ferretti, P, Paddison, P J, Preston, J E, Abbott, N J, Bertone, P, Smith, A & Pollard, S M 2013, ' A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 ', PLoS ONE, vol. 8, no. 10, pp. e77053 . https://doi.org/10.1371/journal.pone.0077053
Danovi, D, Folarin, A, Gogolok, S, Ender, C, Elbatsh, A M O, Engström, P G, Stricker, S H, Gagrica, S, Georgian, A, Yu, D, U, K P, Harvey, K J, Ferretti, P, Paddison, P J, Preston, J, Abbott, N J, Bertone, P, Smith, A & Pollard, S M 2013, ' A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 ', PL o S One, vol. 8, no. 10, e77053 . https://doi.org/10.1371/journal.pone.0077053
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and cellular characteristics of neural stem cells that drive tumour growth. Here we compare resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd080c56601eb859952ebd881c6c796f
https://doi.org/10.1371/journal.pone.0077053
https://doi.org/10.1371/journal.pone.0077053