Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ana R. Calixto"'
Publikováno v:
QRB Discovery, Vol 5 (2024)
Protein tyrosine phosphatases (PTPs) are crucial regulators of cellular signaling. Their activity is regulated by the motion of a conserved loop, the WPD-loop, from a catalytically inactive open to a catalytically active closed conformation. WPD-loop
Externí odkaz:
https://doaj.org/article/32a8f2bafca546caae7c24425fd85836
Autor:
Ruidan Shen, Rory M. Crean, Keith J. Olsen, Marina Corbella, Ana R. Calixto, Teisha Richan, Tiago A. S. Brandão, Ryan D. Berry, Alex Tolman, J. Patrick Loria, Sean J. Johnson, Shina C. L. Kamerlin, Alvan C. Hengge
Publikováno v:
Chemical Science. 13:13524-13540
Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental and computational studies, focused on the huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf6320cf364981151c2ead82fa484b4
https://doi.org/10.1039/d2sc04135a
https://doi.org/10.1039/d2sc04135a
Autor:
Rory M. Crean, Michal Biler, Marina Corbella, Ana R. Calixto, Marc W. van der Kamp, Alvan C. Hengge, Shina C. L. Kamerlin
Publikováno v:
Journal of the American Chemical Society. 144:10091-10093
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10cc37853c8802a3c9e2441b1af774cc
https://doi.org/10.1021/jacs.2c04624
https://doi.org/10.1021/jacs.2c04624
Autor:
Pedro Ferreira, Pedro A. Fernandes, Ana R. Calixto, Maria J. Ramos, Carmay Lim, Sérgio F. Sousa
Publikováno v:
ACS Catalysis. 10:8444-8453
Enzymes are responsible for controlling many biological processes, catalyzing different reactions using substrates with diverse complexity, size, and chemistry. How enzymes work and achieve their catalytic efficiency are some of the fundamental quest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aecf1db0eb26be158916788bc9f7b2f
https://doi.org/10.1021/acscatal.0c01947
https://doi.org/10.1021/acscatal.0c01947
Publikováno v:
ACS Omega, Vol 5, Iss 9, Pp 4380-4385 (2020)
ACS Omega
ACS Omega
GTP hydrolysis is central to biology, being involved in regulating a wide range of cellular processes. However, the mechanisms by which GTPases hydrolyze this critical reaction remain controversial, with multiple mechanistic possibilities having been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a485e5ea39a8e0068cb8fae79961641f
https://doi.org/10.1021/acsomega.0c00240
https://doi.org/10.1021/acsomega.0c00240
Publikováno v:
Biochemical Society Transactions
Structural and biochemical studies on diverse enzymes have highlighted the importance of ligand-gated conformational changes in enzyme catalysis, where the intrinsic binding energy of the common phosphoryl group of their substrates is used to drive e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1bf581222a7123bee2ddf24dd14d9d
http://europepmc.org/articles/PMC6824834
http://europepmc.org/articles/PMC6824834
Publikováno v:
Chemical Science
One enzyme, one substrate, but two different reaction mechanisms: HIV-1 protease follows different reaction mechanisms depending on its instantaneous conformation.
The role of conformational diversity in enzyme catalysis has been a matter of ana
The role of conformational diversity in enzyme catalysis has been a matter of ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3164c230f42637c561e6c0de8d95f5bf
https://doi.org/10.1039/c9sc01464k
https://doi.org/10.1039/c9sc01464k
Publikováno v:
ACS Catalysis. 8:4055-4063
The subset of catalytically competent conformations can be significantly small in comparison with the full conformational landscape of enzyme–substrate complexes. In some enzymes, the probability of finding a reactive conformation can account for u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba0e51322384349d09756720b597ffd6
https://doi.org/10.1021/acscatal.7b04400
https://doi.org/10.1021/acscatal.7b04400
Autor:
Carsten Kötting, Cátia Moreira, Klaus Gerwert, Ana R. Calixto, Shina Caroline Lynn Kamerlin, Till Rudack, Anna Pabis
Publikováno v:
Journal of the American Chemical Society. 141(27)
GTP hydrolysis is a biologically crucial reaction, being involved in regulating almost all cellular processes. As a result, the enzymes that catalyze this reaction are among the most important drug targets. Despite their vital importance and decades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d618fc364738d28d198b0db879729b29
https://pubmed.ncbi.nlm.nih.gov/31199130
https://pubmed.ncbi.nlm.nih.gov/31199130
Autor:
Wael E. Houssen, Marcel Jaspars, Pedro A. Fernandes, James H. Naismith, Maria J. Ramos, Pedro Ferreira, Ana R. Calixto, Natércia F. Brás
Publikováno v:
Chemistry – A European Journal. 27:3569-3569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea63ef36bc055fed4cce76b65819efb
https://doi.org/10.1002/chem.202100062
https://doi.org/10.1002/chem.202100062