Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ana Pocivavsek"'
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Dysregulated sleep is commonly reported in individuals with neuropsychiatric disorders, including schizophrenia (SCZ) and bipolar disorder (BPD). Physiology and pathogenesis of these disorders points to aberrant metabolism, during neurodevel
Externí odkaz:
https://doaj.org/article/3ab2c689e0c645c6b99b50c1523da3a2
Autor:
Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D. Burbano, Prosun K. Das, Helen H. Do, Janet L. Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I. De Zeeuw, Magda A. Meester-Smoor, Beerend H. J. Winkelman, Caroline C. W. Klaver, Ana Pocivavsek, Michy P. Kelly
Publikováno v:
Cells, Vol 12, Iss 24, p 2839 (2023)
Recently, a Y727C variant in the dual-specific 3′,5′-cyclic nucleotide phosphodiesterase 11A (PDE11A-Y727C) was linked to increased sleep quality and reduced myopia risk in humans. Given the well-established role that the PDE11 substrates cAMP an
Externí odkaz:
https://doaj.org/article/afdb21e5db9b413d8cd3d5fd6c0370cf
Publikováno v:
Neurobiology of Stress, Vol 24, Iss , Pp 100543- (2023)
Sleep is a vital and evolutionarily conserved process, critical to daily functioning and homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental physiological outcomes. Despite sleep disturbances affecting everyone
Externí odkaz:
https://doaj.org/article/01014c064f3740fe99265f4d90c8287b
Autor:
Courtney J. Wright, Katherine M. Rentschler, Nathan T. J. Wagner, Ashley M. Lewis, Sarah Beggiato, Ana Pocivavsek
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder. Kynurenic acid (KYNA) has been found to be elevated in postmortem brain tissue and cere
Externí odkaz:
https://doaj.org/article/cd027beb078849a88ffea8c6231e547a
Autor:
Annalisa M. Baratta, Nickole R. Kanyuch, Casey A. Cole, Homayoun Valafar, Jessica Deslauriers, Ana Pocivavsek
Publikováno v:
Neurobiology of Stress, Vol 12, Iss , Pp - (2020)
The kynurenine pathway (KP) is the dominant pathway for tryptophan degradation in the mammalian body and emerging evidence suggests that acute episodes of sleep deprivation (SD) disrupt tryptophan metabolism via the KP. Increases in the neuroactive K
Externí odkaz:
https://doaj.org/article/dbab821fdc4b4db2ab07fac7a7a4b749
Autor:
Annalisa M. Baratta, Silas A. Buck, Austin D. Buchla, Carly B. Fabian, Shuo Chen, Jessica A. Mong, Ana Pocivavsek
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Inadequate sleep is a prevalent problem within our society that can result in cognitive dysfunction. Elevations in kynurenic acid (KYNA), a metabolite of the kynurenine pathway (KP) of tryptophan degradation known to impact cognition, in the
Externí odkaz:
https://doaj.org/article/c449f1093180463b9eafeaffd55713e6
Autor:
Katherine M. Rentschler, Snezana Milosavljevic, Annalisa M. Baratta, Courtney J. Wright, Maria V. Piroli, Zachary Tentor, Homayoun Valafar, Ana Pocivavsek
Patients with neurocognitive disorders often battle sleep disturbances. Kynurenic acid (KYNA) is a tryptophan metabolite of the kynurenine pathway implicated in the pathology of these illnesses. Modest increases in KYNA, an antagonist at glutamatergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c067d2a6bf8ea1030194fdc6e9d4489f
https://doi.org/10.1101/2022.11.21.517377
https://doi.org/10.1101/2022.11.21.517377
Autor:
Courtney J Wright, Nathan T J Wagner, Jessica A. Mong, Ana Pocivavsek, Katherine M Rentschler, Audrey L Ditty, Snezana Milosavljevic, Annalisa M. Baratta
Publikováno v:
Schizophr Bull
Dysregulation of the kynurenine pathway (KP) of tryptophan catabolism has been implicated in psychotic disorders, including schizophrenia and bipolar disorder. Kynurenic acid (KYNA) is a KP metabolite synthesized by kynurenine aminotransferases (KATs
Autor:
Katherine M Rentschler, Nathan T J Wagner, Ana Pocivavsek, Ashley M Lewis, Courtney J Wright, Sarah Beggiato
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 12 (2021)
Frontiers in Psychiatry, Vol 12 (2021)
Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder. Kynurenic acid (KYNA) has been found to be elevated in postmortem brain tissue and cere