The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II

Autor: Marco Trizzino, Elisa Barbieri, Ana Petracovici, Shuai Wu, Sarah A. Welsh, Tori A. Owens, Silvia Licciulli, Rugang Zhang, Alessandro Gardini

Publikováno v: Cell Reports, Vol 23, Iss 13, Pp 3933-3945 (2018)

Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear

Externí odkaz: https://doaj.org/article/aab9c38312a740ed8d32bc849ec677da

Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation

Autor: Ana Petracovici, Roberto Bonasio

Publikováno v: Mol Cell

The Polycomb repressive complex 2 (PRC2) is an essential epigenetic regulator that deposits repressive H3K27me3. PRC2 subunits form two holocomplexes-PRC2.1 and PRC2.2-but the roles of these two PRC2 assemblies during differentiation are unclear. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa34ee5c42add67a2e12620422a67da
https://europepmc.org/articles/PMC8217195/

Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency

Autor: Tiia Reimand, Kirsty McWalter, Eleanor G. Seaby, G. Bradley Schaefer, Marwan Shinawi, Muhammad Arif Nadeem Saqib, Aida Telegrafi, Ana Petracovici, Sander Pajusalu, Jill A. Fahrner, David B. Beck, Chongsheng He, Hannah W. Moore, Suzanne M. Leal, Raymond J. Louie, Siddharth Banka, Renee Bend, Regie Lyn P. Santos-Cortez, Roberto Bonasio, Boris Keren, Marie Christine Nougues, Eloise J. Prijoles, Muhammad Ansar, Katrin Õunap, Roger E. Stevenson, Julien Buratti, Sofia Douzgou, Cyril Mignot, Sivagamy Sithambaram, Trudie Cottrell, Dustin Baldridge, Muhammad Zahid

Publikováno v: Am J Hum Genet
Beck, D B, Petracovici, A, He, C, Moore, H W, Louie, R J, Ansar, M, Douzgou, S, Sithambaram, S, Cottrell, T, Santos-Cortez, R L P, Prijoles, E J, Bend, R, Keren, B, Mignot, C, Nougues, M-C, Õunap, K, Reimand, T, Pajusalu, S, Saqib, M A N, Buratti, J, Seaby, E G, McWalter, K, Telegrafi, A, Baldridge, D, Shinawi, M, Leal, S M, Schaefer, G B, Stevenson, R E, Banka, S, Bonasio, R & Fahrner, J A 2020, ' Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery : TET3 Deficiency ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2019.12.007

Germline pathogenic variants in chromatin-modifying enzymes are a common cause of pediatric developmental disorders. These enzymes catalyze reactions that regulate epigenetic inheritance via histone post-translational modifications and DNA methylatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8a0d323dc150b74b9bd22860ebfb32
https://pubmed.ncbi.nlm.nih.gov/31928709

The tumor suppressor ARID1A controls global transcription via pausing of RNA Polymerase II

Autor: Elisa Barbieri, Sarah A. Welsh, Shuai Wu, Ana Petracovici, Rugang Zhang, Silvia Licciulli, Alessandro Gardini, Tori A. Owens, Marco Trizzino

Publikováno v: Cell Reports, Vol 23, Iss 13, Pp 3933-3945 (2018)

Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351eb332f8785d7bdfe60c85df3612c2
https://europepmc.org/articles/PMC6146183/