Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ana Petra Costa"'
Autor:
Michael H. Court, Katrina L. Mealey, Nicolas F. Villarino, Ana Petra Costa, Neal S. Burke, Zhaohui Zhu
Publikováno v:
Drug Metabolism and Disposition
Drug binding to plasma proteins is routinely determined during drug development. Albumin polymorphisms c.1075G>T (p.Ala359Ser) and c.1422A>T (p.Glu474Asp) were previously shown to alter plasma protein binding of a drug candidate (D01-4582, 4-[1-[3-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8021fe8b2275b4621bcf143534767d65
https://doi.org/10.1124/dmd.119.087304
https://doi.org/10.1124/dmd.119.087304
Publikováno v:
J Vet Pharmacol Ther
Orosomucoid polymorphisms influence plasma drug binding in humans; however, canine variants and their effect on drug plasma protein binding have not yet been reported. In this study, the orosomucoid gene (ORM1) was sequenced in 100 dogs to identify t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e22a2a4a1bfaad1a6ecb5e4090ef01
https://pubmed.ncbi.nlm.nih.gov/32744755
https://pubmed.ncbi.nlm.nih.gov/32744755
Publikováno v:
Journal of Veterinary Cardiology. 16:283-290
A dog evaluated for acute onset of neurologic clinical signs was discovered to have a porcupine quill traversing the left atrium with fungal endocarditis. The dog had been quilled by a porcupine one month prior to presentation and had had several qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efed1d5bef69d96c3bbe5c068f427742
https://doi.org/10.1016/j.jvc.2014.09.003
https://doi.org/10.1016/j.jvc.2014.09.003
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 39(1)
Corticosteroids are one of the most extensively used class of therapeutic agents in dogs. In human patients, response to corticosteroid therapy has been correlated with the presence of certain polymorphisms of the glucocorticoid receptor gene (NR3C1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df06f7ce99cec6f1f6ce98f0363c92ca
https://pubmed.ncbi.nlm.nih.gov/25989385
https://pubmed.ncbi.nlm.nih.gov/25989385