Zobrazeno 1 - 10 of 106 pro vyhledávání: '"Ana Perez‐Castillo"'
1
Akademický článek
Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson’s Disease: The Implication of Lipid Droplets and Lipophagy
Autor: Jesus Alarcon-Gil, Ana Sierra-Magro, Jose A. Morales-Garcia, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Marta Cortes-Canteli, Mireia Niso-Santano, Guadalupe Martínez-Chacón, Jose M. Fuentes, Angel Santos, Ana Perez-Castillo
Publikováno v: Cells, Vol 11, Iss 15, p 2297 (2022)
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves s
Externí odkaz: https://doaj.org/article/bb317495902d454c98df5b75ab6736c7
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2
Akademický článek
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro
Autor: Jose A. Morales-García, Mario de la Fuente Revenga, Sandra Alonso-Gil, María Isabel Rodríguez-Franco, Amanda Feilding, Ana Perez-Castillo, Jordi Riba
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldwide. Animal studies and recent clinical research suggests that B. c
Externí odkaz: https://doaj.org/article/3f69a5bf335241359aa3a50eb6c97777
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3
Akademický článek
Role of C/EBPβ transcription factor in adult hippocampal neurogenesis.
Autor: Marta Cortes-Canteli, Diana Aguilar-Morante, Marina Sanz-Sancristobal, Diego Megias, Angel Santos, Ana Perez-Castillo
Publikováno v: PLoS ONE, Vol 6, Iss 10, p e24842 (2011)
BackgroundThe dentate gyrus of the hippocampus is one of the regions in which neurogenesis takes place in the adult brain. We have previously demonstrated that CCAAT/enhancer binding protein β (C/EBPβ) is expressed in the granular layer of the dent
Externí odkaz: https://doaj.org/article/3a92a4a916b343dfa31affb2dda54df8
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4
Akademický článek
Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
Autor: Jose A Morales-Garcia, Miriam Redondo, Sandra Alonso-Gil, Carmen Gil, Concepción Perez, Ana Martinez, Angel Santos, Ana Perez-Castillo
Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17240 (2011)
BACKGROUND: Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many cell types. This cyclic nucleotide plays a key role in signal transduction in a wide variety of cellular responses. In the
Externí odkaz: https://doaj.org/article/61f7c3ecf9b34a8bae3836549f2e759b
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5
Akademický článek
Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.
Autor: Diana Aguilar-Morante, Jose Angel Morales-Garcia, Marina Sanz-SanCristobal, Miguel Angel Garcia-Cabezas, Angel Santos, Ana Perez-Castillo
Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13879 (2010)
Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3β (GSK-3β). In this study, we analyzed the effects of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-
Externí odkaz: https://doaj.org/article/609a34d1bb4a4fd18a3643e31399bafc
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9
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Autor: Dolores Viña, Erik Laurini, Concepción Pérez, José A. Morales-García, Eva Ramos, Sabrina Pricl, María Isabel Rodríguez-Franco, Ana Perez-Castillo, Clara Herrera-Arozamena, Alejandro Romero, Martín Estrada-Valencia
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 712-727 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades could be the so long wanted rem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2268ce68b4d3f496cbf99e667b2ec2a1
https://doaj.org/article/ed3ffb901f804e3298167947f93fccbc
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