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Postpartum perineal pain and dyspareunia related to each superficial perineal muscle injury: a cohort study

Autor: Carmen Terré-Rull, Sara S. Webb, Margarita Manresa, Eduardo Bataller, Josefina Goberna-Tricas, Ana Pereda

Publikováno v: International urogynecology journal. 31(11)

To assess the association between superficial perineal muscle trauma and perineal pain and dyspareunia.Prospective cohort study of 405 women with a spontaneous vaginal birth comparing an intact perineum and first-degree perineal trauma group (n = 205

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c495a65dc112d363b929a51eb8b94eeb
https://pubmed.ncbi.nlm.nih.gov/32405659

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Incidence of perineal pain and dyspareunia following spontaneous vaginal birth: a systematic review and meta-analysis

Autor: Margarita Manresa, Ana Pereda, Khaled M. Ismail, Carmen Terré-Rull, Sara S. Webb, Eduardo Bataller

Publikováno v: International urogynecology journal. 30(6)

Perineal pain and dyspareunia are experienced by women undergoing a vaginal birth that can have short and longer term physical and psychological morbidities. This review aimed to determine the incidence of perineal pain and dyspareunia following spon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8948c25c8a85ce7b24abb92a3bd266
https://pubmed.ncbi.nlm.nih.gov/30770967

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Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

Autor: Philip J. Hajduk, John E. Harlan, Ulrich Ebert, Robert W. Johnson, Stefan Barghorn, Larry R. Solomon, Thomas F. Holzman, Boris Labkovsky, Heinz Hillen, Edward T. Olejniczak, Rohinton Edalji, Karl A. Walter, Liping Yu, Paul L. Richardson, Laura J. Miesbauer, Diane Bartley, Ana Pereda Lopez

Publikováno v: Biochemistry. 48:1870-1877

Alzheimer's disease (AD) is a neurodegenerative disorder that is linked to the presence of amyloid beta-peptides that can form insoluble fibrils or soluble oligomeric assemblies. Soluble forms are present in the brains and tissues of Alzheimer's pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457039242f221b4027522f6e3cf1430e
https://doi.org/10.1021/bi802046n

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Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin

Autor: Jie Wang, Edmund D. Matayoshi, Edward T. Olejniczak, Ana Pereda-Lopez, Philip J. Hajduk, Liping Yu, Chaohong Sun, Eric J. Hebert, Renaldo Mendoza

Publikováno v: Protein Science. 16:2502-2509

Calsenilin is a member of the recoverin branch of the EF-hand superfamily that is reported to interact with presenilins, regulate prodynorphin gene expression, modulate voltage-gated Kv4 potassium channel function, and bind to neurotoxins. Calsenilin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1e43e94b5f991d8439ab00ccf8c258
https://doi.org/10.1110/ps.072928007

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Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-R S

Autor: Paul L. Richardson, Victoria E. Scott, Marie E. Uchic, Larry Solomon, Edward T. Olejniczak, Karl A. Walter, Rachel Davis-Taber, Danying Song, Chaohong Sun, Leo W. Barrett, Ana Pereda-Lopez, Philip J. Hajduk, Marc R. Lake

Publikováno v: Proceedings of the National Academy of Sciences. 104:7875-7880

The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic plasticity. The soluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c62621b818f70dc9bd76d1e57a970e
https://doi.org/10.1073/pnas.0611397104

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Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists

Autor: Steven Cassar, Karl A. Walter, Jing Xu, Jun Chen, Reza S. Sabet, Connie R. Faltynek, Steve D. Pratt, Robert B. Moreland, Victoria E. Scott, Usha Warrior, Sujatha M. Gopalakrishnan, Marc R. Lake, Ana Pereda-Lopez, Thomas F. Holzman, Murali Gopalakrishnan, Wende Niforatos

Publikováno v: SLAS Discovery. 12:61-69

Despite increasing use of cell-based assays in high-throughput screening (HTS) and lead optimization, one challenge is the adequate supply of high-quality cells expressing the target of interest. To this end, cell lines stably expressing targets are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ea308aa5e2e3b84c14ced34883d005
https://doi.org/10.1177/1087057106295220

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Cracking the molecular weight barrier: Fragment screening of an aminotransferase using an NMR-based functional assay

Autor: Ana Pereda-Lopez, Yaya Liu, Andrew M. Petros, Sanjay C. Panchal, Rama Thimmapaya, Renaldo Mendoza, Chaohong Sun, Walter F. Leise, Carol S. Surowy

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:5248-5250

NMR-based screening of protein targets has become a well established part of the drug discovery process especially with respect to fragments. However, as target size increases the two-dimensional spectra typically used for such screening become more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc330c39f21c88a5f0b62424e147f6c
https://doi.org/10.1016/j.bmcl.2011.07.039

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