Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ana Paula Mendes-Silva"'
Autor:
Serena Mares Malta, Tamiris Sabrina Rodrigues, Matheus Henrique Silva, Alexandre Souza Marquez, Rafael Bernardes Ferreira, Fernanda Naves Araújo do Prado Mascarenhas, Renata Graciele Zanon, Lucas Matos Martins Bernardes, Letícia Leandro Batista, Murillo Néia Thomaz da Silva, Débora de Oliveira Santos, Ana Carolina Costa Santos, Ana Paula Mendes-Silva, Foued Salmen Spindola, Carlos Ueira-Vieira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative condition and the primary form of dementia among elderly people. The amyloidogenic hypothesis is the main theory that explains this phenomenon and describes the extracellular accu
Externí odkaz:
https://doaj.org/article/0f1a3040b47c4baabae9e4c61ddccbf3
Autor:
Ana Paula Mendes-Silva, Thomas Damien Prevot, Mounira Banasr, Etienne Sibille, Breno Satler Diniz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
BackgroundThe cell cycle is a critical mechanism for proper cellular growth, development and viability. The p16INK4a and p21Waf1/Cip1 are important regulators of the cell cycle progression in response to internal and external stimuli (e.g., stress).
Externí odkaz:
https://doaj.org/article/06ea96e31ba9434c902f032181992691
Autor:
Ana Paula Mendes‐Silva, Erica Leandro Marciano Vieira, Gabriela Xavier, Lucelia Scarabeli Silva Barroso, Laiss Bertola, Efrem Augusto Ribeiro Martins, Elisa Macedo Brietzke, Sintia Iole Nogueira Belangero, Breno Satler Diniz
Publikováno v:
Brain and Behavior, Vol 11, Iss 8, Pp n/a-n/a (2021)
Abstract Objectives Telomeres are structures at the extremity of chromosomes that prevents genomic instability, and its shortening seems to be a hallmark of cellular aging. Past studies have shown contradictory results of telomere length (TL) in majo
Externí odkaz:
https://doaj.org/article/bd9be764d0f54ff69339cc2ab9ba5c9d
Autor:
Breno S. Diniz, Erica M. Vieira, Ana Paula Mendes‐Silva, Christopher R. Bowie, Meryl A. Butters, Corinne E. Fischer, Alastair Flint, Nathan Herrmann, James Kennedy, Krista L. Lanctôt, Linda Mah, Bruce G. Pollock, Benoit H. Mulsant, Tarek K. Rajji, on behalf of the PACt‐MD Study Group
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major
Externí odkaz:
https://doaj.org/article/0c6641d614e74407aa3bc553147c6eee
Autor:
Johanna Seitz-Holland, Benoit H. Mulsant, Charles F. Reynolds III, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Eric J. Lenze, Breno S. Diniz
Publikováno v:
Nature Mental Health. 1:200-209
Previous studies suggested the role of cellular senescence in late-life depression (LLD). However, it is unclear how this finding relates to common features of LLD, such as medical and cognitive problems. We applied factor analyses to an extensive ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eeb575e79e44c319b78dbf2a2d5446a
https://doi.org/10.1038/s44220-023-00033-z
https://doi.org/10.1038/s44220-023-00033-z
Autor:
Johanna Seitz-Holland, Benoit H. Mulsant, Charles F. Reynolds, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Eric J. Lenze, Breno S. Diniz
Publikováno v:
Biological Psychiatry. 93:S133-S134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60703c7b8def750cdddb62c7f16908ca
https://doi.org/10.1016/j.biopsych.2023.02.338
https://doi.org/10.1016/j.biopsych.2023.02.338
Autor:
Emma Mastrobattista, Eric J. Lenze, Charles F. Reynolds, Benoit H. Mulsant, Julie Wetherell, Gregory F. Wu, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Breno S. Diniz
Publikováno v:
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 31(1)
In older adults, major depressive disorder (MDD) is associated with accelerated physiological and cognitive aging, generating interest in uncovering biological pathways that may be targetable by interventions. Growth differentiation factor-15 (GDF-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030fcdd76ba85e161f5e9c5c5f8a5a68
https://pubmed.ncbi.nlm.nih.gov/36153290
https://pubmed.ncbi.nlm.nih.gov/36153290
Autor:
Jéssica Regina da Costa Silva, Patrícia Tieme Fujimura, Letícia Leandro Batista, Serena Mares Malta, Romualdo Morandi Filho, Matheus Henrique Silva, Aline Gomes de Souza, Ana Paula Mendes Silva, Luiza Diniz Ferreira Borges, Victor Alexandre Félix Bastos, Jamile Fernanda Silva Cossolin, José Eduardo Serrão, Ana Maria Bonetti, Luiz Carlos Oliveira Júnior, Carlos Ueira-Vieira
Alzheimer's disease (AD) is characterized by progressive, irreversible loss of memory and cognitive function. Drosophila melanogaster and other animal models are used to study several diseases, in order to elucidate unknown mechanisms and develop pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44805a1c85ba40fc3f64508f5cfe6bdd
http://hdl.handle.net/11573/1643979
http://hdl.handle.net/11573/1643979
Autor:
Licia C, Silva-Costa, Bradley J, Smith, Victor Corasolla, Carregari, Gustavo H M F, Souza, Erica M, Vieira, Ana Paula, Mendes-Silva, Valéria, de Almeida, Benilton S, Carvalho, Breno S, Diniz, Daniel, Martins-de-Souza
Publikováno v:
Journal of Proteomics. 269:104713
Depression is a complex and multifactorial disease, affecting about 6.5% of the elderly population in what is referred to as late-life depression (LLD). Despite its public health relevance, there is still limited information about the molecular mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c515fb77acd7b24f296249791159d614
https://doi.org/10.1016/j.jprot.2022.104713
https://doi.org/10.1016/j.jprot.2022.104713
Autor:
Vanessa F. Gonçalves, Ana Paula Mendes-Silva, Jenna M. Bartley, Emi Ampo, Breno S. Diniz, George A. Kuchel
Publikováno v:
Am J Geriatr Psychiatry
Objective To evaluate the circulating cell-free mitochondrial DNA (ccf-mtDNA) levels, a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. We hypothesize that individuals with both frailty and LLD will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6814c008a3496858a766b6bb60c4a1d9
https://europepmc.org/articles/PMC8799751/
https://europepmc.org/articles/PMC8799751/