Výsledky vyhledávání - "Ana P. Goncalvez"

Chimeric yellow fever 17D-Zika virus (ChimeriVax-Zika) as a live-attenuated Zika virus vaccine

Autor: Nicolas Jackson, Francisco Maldonado-Arocho, Valerie Lecouturier, Ana P. Goncalvez, Raul C. Gomila, Harold Kleanthous, Diaz Fernando Martin, Nicolas Burdin, John Catalan, Maryann Giel-Moloney, Simon Delagrave, Ray Oomen, Konstantin V. Pugachev, Jon Heinrichs, Marie-Clotilde Bernard, Yves Girerd-Chambaz

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e483ad53c7dceb172d3263b115e6b290
http://europepmc.org/articles/PMC6123396

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Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus

Autor: Leonid V. Chernomordik, Félix A. Rey, Stéphane Duquerroy, Ana P. Goncalvez, M. Erika Navarro Sanchez, Philippe Dussart, Elena Zaitseva, Carlos M. Kikuti, Joseph J.B. Cockburn, Enrico A. Stura, Ching-Juh Lai

Publikováno v: The EMBO Journal. 31:767-779

The four serotypes of dengue virus (DENV-1 to -4) cause the most important emerging viral disease. Protein E, the principal viral envelope glycoprotein, mediates fusion of the viral and endosomal membranes during virus entry and is the target of neut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f286aded5406c5cba77b34750ecfa45e
https://doi.org/10.1038/emboj.2011.439

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Dengue virus neutralization is modulated by IgG antibody subclass and Fcγ receptor subtype

Autor: Ana P. Goncalvez, Syd Johnson, Michael S. Diamond, Olivia K. T. Block, Xia Jin, Ching Juh Lai, Jacob J. Schlesinger, Robert C. Rose, Soila Sukupolvi-Petty, Christopher Lane, W. W. Shanaka I. Rodrigo

Publikováno v: Virology. 394(2):175-182

Severe dengue virus (DENV) infection is epidemiologically linked to pre-existing anti-DENV antibodies acquired by maternal transfer or primary infection. A possible explanation is that DENV immune complexes evade neutralization by engaging Fcgamma re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fe06dc1d06dc8e1a9fa513e4a4ac3e

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Epitope Determinants of a Chimpanzee Dengue Virus Type 4 (DENV-4)-Neutralizing Antibody and Protection against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized Antibody

Autor: Claire Wernly, Ching-Juh Lai, Ruhe Men, Robert H. Purcell, Olivia K. Donau, Ana P. Goncalvez, Ronald E. Engle

Publikováno v: Journal of Virology. 81:12766-12774

The chimpanzee monoclonal antibody (MAb) 5H2 is specific for dengue virus type 4 (DENV-4) and neutralizes the virus at a high titer in vitro. The epitope detected by the antibody was mapped by sequencing neutralization escape variants of the virus. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a8253738dbfb9906b365e1aa2c29ac
https://doi.org/10.1128/jvi.01420-07

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Monoclonal antibody-mediated enhancement of dengue virus infectionin vitroandin vivoand strategies for prevention

Autor: Ching-Juh Lai, Ronald E. Engle, Ana P. Goncalvez, Robert H. Purcell, Marisa St. Claire

Publikováno v: Proceedings of the National Academy of Sciences

Infection with dengue virus (DENV) or any other flavivirus induces cross-reactive, but weakly neutralizing or nonneutralizing, antibodies that recognize epitopes involving the fusion peptide in the envelope glycoprotein. Humanized mAb IgG 1A5, derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5f03089223a59601740592e1b79dfa
https://doi.org/10.1073/pnas.0703498104

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Epitope Determinants of a Chimpanzee Fab Antibody That Efficiently Cross-Neutralizes Dengue Type 1 and Type 2 Viruses Map to Inside and in Close Proximity to Fusion Loop of the Dengue Type 2 Virus Envelope Glycoprotein

Autor: Ching-Juh Lai, Ana P. Goncalvez, Robert H. Purcell

Publikováno v: Journal of Virology. 78:12919-12928

The epitope determinants of chimpanzee Fab antibody 1A5, which have been shown to be broadly reactive to flaviviruses and efficient for cross-neutralization of dengue virus type 1 and type 2 (DENV-1 and DENV-2), were studied by analysis of DENV-2 ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6465290a04bb910d7f159577222a1cfd
https://doi.org/10.1128/jvi.78.23.12919-12928.2004

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Single-dose vaccine against tick-borne encephalitis

Autor: Harry Kleanthous, Maryann Giel-Moloney, Yuxi Liu, John Catalan, Alexander A. Rumyantsev, Jeff Almond, Konstantin V. Pugachev, Qing-sheng Gao, Ana P. Goncalvez

Tick-borne encephalitis (TBE) virus is the most important human pathogen transmitted by ticks in Eurasia. Inactivated vaccines are available but require multiple doses and frequent boosters to induce and maintain immunity. Thus far, the goal of devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5db3201c1b62f60842b71b9fdb65930
https://europepmc.org/articles/PMC3740852/

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Humanized Monoclonal Antibodies Derived from Chimpanzee Fabs Protect against Japanese Encephalitis Virus In Vitro and In Vivo ▿

Autor: Inna Gorshkova, Ching-Juh Lai, Carrie Roll, Cheng-Hsin Chien, Ana P. Goncalvez, Sutee Yoksan, Sy-Dar Wang, Kamolchanok Tubthong, Peter Schuck, Robert H. Purcell, Olivia K. Donau

Japanese encephalitis virus (JEV)-specific Fab antibodies were recovered by repertoire cloning from chimpanzees initially immunized with inactivated JE-VAX and then boosted with attenuated JEV SA14-14-2. From a panel of 11 Fabs recovered by different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85109171145585ed0be5905a9249ace
https://europepmc.org/articles/PMC2446956/

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Identification of chimpanzee Fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin G1 antibody that is highly efficient for neutralization of dengue type 4 virus

Autor: Claire Wernly, Ana P. Goncalvez, Suzanne U. Emerson, Darren J. Schofield, Ruhe Men, Ching-Juh Lai, Tetsu Yamashiro, Robert H. Purcell

Publikováno v: Journal of virology. 78(9)

A safe and effective dengue vaccine is still not available. Passive immunization with monoclonal antibodies from humans or nonhuman primates represents an attractive alternative for the prevention of dengue virus infection. Fab monoclonal antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0930084161de1588e6586b36f04a5e50
https://pubmed.ncbi.nlm.nih.gov/15078949

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