Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ana P. Castano"'
Autor:
Rebecca C. Larson, Michael C. Kann, Charlotte Graham, Christopher W. Mount, Ana P. Castano, Won-Ho Lee, Amanda A. Bouffard, Hana N. Takei, Antonio J. Almazan, Irene Scarfó, Trisha R. Berger, Andrea Schmidts, Matthew J. Frigault, Kathleen M. E. Gallagher, Marcela V. Maus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence s
Externí odkaz:
https://doaj.org/article/008a498ec868469ca7437a0db7630ab9
Autor:
Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3248-3260 (2019)
Abstract: Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BC
Externí odkaz:
https://doaj.org/article/744190eefb7f4eac95dde4520a55224b
Autor:
Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson, Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey, Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts, Jason G. Sagert, William T. Curry, Bob S. Carter, Marcela V. Maus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfun
Externí odkaz:
https://doaj.org/article/987e2dc848b84c4ebabd4c5eacf43cbb
Autor:
Marcela V. Maus, Matthew J. Frigault, Torben Barington, David M. Weinstock, Henrik J. Ditzel, Morten F. Gjerstorff, Jacob H. Christensen, Charlotte G. Nyvold, Oriane Cédile, Rikke S. Andersen, Bryan D. Choi, Andrea Schmidts, Lauren S. Riley, Rebecca C. Larson, Ana P. Castano, Amanda A. Bouffard, Selena J. Lorrey, Stefanie R. Bailey, Maria L. Cabral, Irene Scarfò, Maria Ormhøj
Supplementary Materials and Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4582e5857ca892ad3132a1732e1514a3
https://doi.org/10.1158/1078-0432.22471292.v1
https://doi.org/10.1158/1078-0432.22471292.v1
Autor:
Marcela V. Maus, Matthew J. Frigault, Torben Barington, David M. Weinstock, Henrik J. Ditzel, Morten F. Gjerstorff, Jacob H. Christensen, Charlotte G. Nyvold, Oriane Cédile, Rikke S. Andersen, Bryan D. Choi, Andrea Schmidts, Lauren S. Riley, Rebecca C. Larson, Ana P. Castano, Amanda A. Bouffard, Selena J. Lorrey, Stefanie R. Bailey, Maria L. Cabral, Irene Scarfò, Maria Ormhøj
Purpose:T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large B-cell lymphoma. Despite the success and curative potential of CD19 CAR T cells, se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dd747a9509cb3fb9a52f5ceb15ca80
https://doi.org/10.1158/1078-0432.c.6527840.v1
https://doi.org/10.1158/1078-0432.c.6527840.v1
Autor:
Sailaja Ghanta, Bonna Ith, Min-Young Kwon, Ana P. Castano, James A. Lederer, Julie Ng, Xiaoli Liu, Junwen Han, Souheil El-Chemaly, Mark A. Perrella, Su Wol Chung
Publikováno v:
Journal of Leukocyte Biology
High mobility group (HMG)A proteins are nonhistone chromatin proteins that bind to the minor groove of DNA, interact with transcriptional machinery, and facilitate DNA‐directed nuclear processes. HMGA1 has been shown to regulate genes involved with
Autor:
Matan Hofree, Robert Morris, Nemanja D. Marjanovic, Joshua Gould, Caroline B. M. Porter, Kirk Gosik, Orr Ashenberg, Ana P. Castano, Marcela V. Maus, Lauren S. Riley, Selena J. Lorrey, Samantha J. Riesenfeld, Rebecca C. Larson, Bryan D. Choi, Livnat Jerby, Trisha R. Berger, Gabriela Smith-Rosario, Aviv Regev, Angela C. Boroughs, Orit Rozenblatt-Rosen
Publikováno v:
Mol Ther
T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have produced impressive outcomes for the treatment of B cell malignancies, but different products vary in kinetics, persistence, and toxicity profiles based on the co-sti
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundGenetic engineering of T cells to express anti-CD19 Chimeric Antigen Receptors (CAR-T cells) has been FDA approved for the treatment of refractory/relapsing acute lymphocytic leukemia and diffuse large B cell lymphoma. With more patients re
Autor:
Amanda A. Bouffard, Kenneth C. Anderson, Lauren S. Riley, Bryan D. Choi, Ana P. Castano, Rebecca C. Larson, Wolfgang W. A. Schamel, Yu-Tzu Tai, Matthew J. Frigault, Andrea Schmidts, Marcela V. Maus, Sean G Mackay, Maria Ormhøj, Maria L. Cabral, Rubí M.-H. Velasco Cárdenas, Jing Zhou, Irene Scarfò, Kathleen Gallagher, Angela C. Boroughs, Allison Taylor
Publikováno v:
Schmidts, A, Ormhøj, M, Choi, B D, Taylor, A O, Bouffard, A A, Scarfò, I, Larson, R C, Frigault, M J, Gallagher, K, Castano, A P, Riley, L S, Cabral, M L, Boroughs, A C, Velasco Cárdenas, R M H, Schamel, W, Zhou, J, Mackay, S, Tai, Y T, Anderson, K C & Maus, M V 2019, ' Rational design of a trimeric April-based CAR-binding domain enables efficient targeting of multiple myeloma ', Blood Advances, vol. 3, no. 21, pp. 3248-3260 . https://doi.org/10.1182/bloodadvances.2019000703
Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BCMA) has pr
Autor:
Bryan D. Choi, Shadmehr Demehri, Bob S. Carter, William T. Curry, Stefanie R. Bailey, Ana P. Castano, Brian V. Nahed, Mark B. Leick, Marcela V. Maus, Irene Scarfò, Curtis L. Cetrulo, Andrea Schmidts, Hiroaki Wakimoto, Rebecca C. Larson, Amanda A. Bouffard, Xiaoling Yu, Daniel P. Cahill, Angela C. Boroughs, Matthew J. Frigault
Publikováno v:
Nature Biotechnology. 37:1049-1058
Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to heterogeneous target antigen expression and outgrowth of tumors lacking the antigen targeted by CAR-T cells directed against single antigens. Here, we developed a bicis