Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ana Mitanoska"'
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma
Autor:
Erdong Wei, Ana Mitanoska, Quinn O’Brien, Kendall Porter, MacKenzie Molina, Haseeb Ahsan, Usuk Jung, Lauren Mills, Michael Kyba, Darko Bosnakovski
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1. We show that pharmacological targeting of the EWS::FLI1 transcriptional complex via inhibition of P300/CBP drives
Externí odkaz:
https://doaj.org/article/3923b7e698e143889b1d963ad608e92e
Autor:
Darko Bosnakovski, David Oyler, Ana Mitanoska, Madison Douglas, Elizabeth T. Ener, Ahmed S. Shams, Michael Kyba
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 1983 (2022)
FSHD is caused by loss of silencing of the DUX4 gene, but the DUX4 protein has not yet been directly detected immunohistologically in affected muscle, raising the possibility that DUX4 expression may occur at time points prior to obtaining adult biop
Externí odkaz:
https://doaj.org/article/6004c77f508143bc95c5736325e346bd
Autor:
Gagan Bajwa, Michelina Iacovino, Elisabeth Mahen, Danielle Rux, Darko Bosnakovski, Holger Fey, Ana Mitanoska, Michael Kyba, Zhaohui Xu
Publikováno v:
Stem cells (Dayton, Ohio). 29(10)
Genetic modification is critically enabling for studies addressing specification and maintenance of cell fate; however, methods for engineering modifications are inefficient. We demonstrate a rapid and efficient recombination system in which an induc