Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ana Miar"'
Autor:
Ceren Yalaz, Esther Bridges, Nasullah K. Alham, Christos E. Zois, Jianzhou Chen, Karim Bensaad, Ana Miar, Elisabete Pires, Ruth J. Muschel, James S. O. McCullagh, Adrian L. Harris
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-26 (2024)
Abstract Background PDE6H encodes PDE6γ′, the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases cGMP levels. The purp
Externí odkaz:
https://doaj.org/article/a0980800c2ff4d25880a8bc551833cad
Autor:
Pahala Gedara Jayathilake, Pedro Victori, Clara E Pavillet, Chang Heon Lee, Dimitrios Voukantsis, Ana Miar, Anjali Arora, Adrian L Harris, Karl J Morten, Francesca M Buffa
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011944 (2024)
Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional. However, the lower energy efficiency of
Externí odkaz:
https://doaj.org/article/0eb01951447743aaa95598c797984cf8
Autor:
Charalampos P. Triantafyllidis, Alessandro Barberis, Fiona Hartley, Ana Miar Cuervo, Enio Gjerga, Philip Charlton, Linda van Bijsterveldt, Julio Saez Rodriguez, Francesca M. Buffa
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108291- (2023)
Summary: TP53, the Guardian of the Genome, is the most frequently mutated gene in human cancers and the functional characterization of its regulation is fundamental. To address this we employ two strategies: machine learning to predict the mutation s
Externí odkaz:
https://doaj.org/article/cfd2574106b94ea7810fc1afdf22fe39
Autor:
Triantafyllidis, Charalampos P., Barberis, Alessandro, Hartley, Fiona, Cuervo, Ana Miar, Gjerga, Enio, Charlton, Philip, van Bijsterveldt, Linda, Rodriguez, Julio Saez, Buffa, Francesca M.
Publikováno v:
In iScience 15 December 2023 26(12)
Autor:
Esther Arnaiz, Ana Miar, Esther Bridges, Naveen Prasad, Stephanie B. Hatch, Daniel Ebner, Charles H. Lawrie, Adrian L. Harris
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF1α and HIF2α. As HIF2α is the driver of the disease promoting tumour growth and metasta
Externí odkaz:
https://doaj.org/article/8896e1e3a353459892656f053ff5e009
Akademický článek
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Autor:
Esther Arnaiz, Ana Miar, Antonio Gregorio Dias Junior, Naveen Prasad, Ulrike Schulze, Dominic Waithe, James A. Nathan, Jan Rehwinkel, Adrian L. Harris
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. Hypoxia promotes local immunosuppression and downregulates type I interferon (IFN) expression and signalling, which contribute to the success of many cancer t
Externí odkaz:
https://doaj.org/article/4651a3ea482c498db9341a48c3118d06
Autor:
Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response
Externí odkaz:
https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc868
Autor:
Adrian L. Harris, Jan Rehwinkel, Robert A. Beagrie, Damien J. Downes, Adam P. Cribbs, Shaunna Beedie, Esther Bridges, Esther Arnaiz, Ana Miar
supplementary figures and materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d1341a9a194aa22c8cc33aa80f00fd
https://doi.org/10.1158/0008-5472.22425273
https://doi.org/10.1158/0008-5472.22425273
Autor:
Adrian L. Harris, Jan Rehwinkel, Robert A. Beagrie, Damien J. Downes, Adam P. Cribbs, Shaunna Beedie, Esther Bridges, Esther Arnaiz, Ana Miar
Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type I IFN supports cytotoxic T lymphocytes by stimulating the maturation of dendr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a36017e08dcfdc433af4999b4d5f00b
https://doi.org/10.1158/0008-5472.c.6511992
https://doi.org/10.1158/0008-5472.c.6511992