Výsledky vyhledávání - "Ana Mercy S. Brito"

The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain

Autor: Renes R. Machado, Márcio M. Coelho, Ivo S.F. Melo, Marcela M.G.B. Dutra, Adriana M. Godin, Tamires C. Matsui, Wagner G. Canhestro, Ângelo de Fátima, Ana Mercy S. Brito, Ricardo José Alves, Giovanna M.E. Coura, Débora P. Araújo, Carla R.A. Batista

Publikováno v: Pharmacological Reports. 71:1177-1183

Phthalimide analogues devoid of the glutarimide moiety exhibit multiple biological activities, thus making them candidates for the treatment of patients with different diseases, including those with inflammatory and painful disorders. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae93c2a1cd16bee68f042aa0837bd3e
https://doi.org/10.1016/j.pharep.2019.08.001

Zobrazit plný text záznamu

Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1

Autor: Marcela I. Morais, Raquel R. Menezes, Felipe F. Rodrigues, Márcio M. Coelho, Sarah O.A.M. Costa, Ivo S.F. Melo, Marcela G.M.B. Dutra, Ana Mercy S. Brito, Renes R. Machado, Franciele A. Goulart, Paulo S. A. Augusto, Adriana M. Godin

Publikováno v: European Journal of Pharmacology. 818:17-25

Leflunomide, an immunosuppressive drug approved for the treatment of patients with rheumatoid arthritis, exhibits many mechanisms which may affect the nociceptive processing. Therefore, the present study aimed to evaluate the effect induced by leflun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a5b1425febef8fabdea73942671329
https://doi.org/10.1016/j.ejphar.2017.10.026

Zobrazit plný text záznamu

2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation

Autor: Ana Mercy S. Brito, Giovanna M.E. Coura, Raquel R. Menezes, Mauro M. Teixeira, Adriana M. Godin, Ivo S.F. Melo, Débora P. Araújo, Ângelo de Fátima, Márcio M. Coelho, Flávio A. Amaral, Renes R. Machado, Leandro F.S. Bastos

Publikováno v: Pharmacological Reports. 69:691-695

Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51af0ca37e14f726b50b8c93aebd13ba
https://doi.org/10.1016/j.pharep.2017.01.033

Zobrazit plný text záznamu

Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms

Autor: Gerson Antônio Pianetti, Leandro F.S. Bastos, Mariana O. Almeida, Ivo S.F. Melo, Renes R. Machado, Carla R.A. Batista, Tamires C. Matsui, Márcio M. Coelho, Ricardo Martins Duarte Byrro, Isabela Costa César, Ângelo de Fátima, Giovanna M.E. Coura, Adriana M. Godin, Ana Mercy S. Brito, Débora P. Araújo, Raquel R. Menezes

Publikováno v: European Journal of Pharmacology. 756:59-66

The activities of 2-phthalimidethyl nitrate (PTD-NO) and 2-phthalimidethanol (PTD-OH) were recently demonstrated in models of pain and inflammation. We expanded our investigation by evaluating their activities in models of nociceptive and inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3c7ee0301f9c4f9de891b817b6da71
https://doi.org/10.1016/j.ejphar.2015.02.052

Zobrazit plný text záznamu

Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema

Autor: Ana Mercy S. Brito, Mauro M. Teixeira, Daniel Assis Santos, Márcio M. Coelho, Darly G. Soares, Renes R. Machado, Ângelo de Fátima, Julliana Ribeiro Alves Santos, Daiane Boff, Lucas S. Ribeiro, Leandro F.S. Bastos, Débora P. Araújo, Raquel R. Menezes, Flávio A. Amaral, Giovanna M.E. Coura, Ivo S.F. Melo, Adriana M. Godin

Publikováno v: Pharmacology Biochemistry and Behavior. 122:291-298

The reintroduction of thalidomide in the pharmacotherapy greatly stimulated the interest in the synthesis and pharmacological evaluation of phthalimide analogs with new and improved activities and also greater safety. In the present study, we evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a2a793abe2b45818394e8bbfa3626e
https://doi.org/10.1016/j.pbb.2014.04.008

Zobrazit plný text záznamu

Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund's adjuvant

Autor: Renes R. Machado, Ivo S.F. Melo, Felipe F. Rodrigues, Tony P. Paulino, Márcio M. Coelho, Giovanna M.E. Coura, Caryne M. Bertollo, Adriana M. Godin, Milene Alvarenga Rachid, Raquel R. Menezes, Ana Mercy S. Brito

Publikováno v: Pharmacological reports : PR. 69(5)

Background The effects induced by thiamine and riboflavin, isolated or in association with corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the effect induced by these B vitamins, isolated or in association with de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfec21a41167a1facd2380a01a6e9323
https://pubmed.ncbi.nlm.nih.gov/28958614

Zobrazit plný text záznamu

Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain

Autor: Paulo S. A. Augusto, de Fátima Â, Márcio M. Coelho, Nascimento Júnior Eb, Ana Mercy S. Brito, Adriana M. Godin, Felipe F. Rodrigues, Débora P. Araújo, Renes R. Machado, Ivo S.F. Melo, Dutra Mm

Publikováno v: European journal of pharmacology. 768

We have previously demonstrated that nicorandil inhibits the second phase of the nociceptive response induced by formaldehyde. In the present study, we evaluated the effects induced by nicorandil in other models of nociceptive and inflammatory pain i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6400bfa1e17dc162749ff0602555c7ec
https://pubmed.ncbi.nlm.nih.gov/26522924

Zobrazit plný text záznamu

Anti-inflammatory and antinociceptive activities of azadirachtin in mice

Autor: Tony P. Paulino, Ivo S.F. Melo, Danielle G. Souza, Rafaela D. Nogueira, Giovanna M.E. Coura, Raquel R. Menezes, Márcio M. Coelho, Adriana M. Godin, Renes R. Machado, Darly G. Soares, Flávio A. Amaral, Ana Mercy S. Brito

Publikováno v: Planta medica. 80(8-9)

Azadirachta indica (Meliaceae) extracts have been reported to exhibit anti-inflammatory and antinociceptive properties. However, the activities of azadirachtin, a limonoid and the major bioactive compound found in the extracts, have been poorly inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4e66685ec4e767072b579c2356b17c
https://pubmed.ncbi.nlm.nih.gov/24871207

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání