Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ana Martinez-Val"'
Autor:
Jose Manuel Rodríguez, Inmaculada Jorge, Ana Martinez-Val, Rafael Barrero-Rodríguez, Ricardo Magni, Estefanía Núñez, Andrea Laguillo, Cristina A. Devesa, Juan A. López, Emilio Camafeita, Jesús Vázquez
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 452-459 (2024)
Many bioinformatics tools are available for the quantitative analysis of proteomics experiments. Most of these tools use a dedicated statistical model to derive absolute quantitative protein values from mass spectrometry (MS) data. Here, we present i
Externí odkaz:
https://doaj.org/article/1bb889184c32408b9304420e981e536e
Autor:
Claire Koenig, Ana Martinez-Val, Previn Naicker, Stoyan Stoychev, Justin Jordaan, Jesper V. Olsen
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102536- (2023)
Summary: Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a mod
Externí odkaz:
https://doaj.org/article/9ba21261ada24d17b97598b856fe573d
Autor:
Chanchal Chauhan, Ana Martinez-Val, Rainer Niedenthal, Jesper Velgaard Olsen, Alexey Kotlyarov, Simon Bekker-Jensen, Matthias Gaestel, Manoj B. Menon
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling,
Externí odkaz:
https://doaj.org/article/842e471da4e14b86910bc06814c7448e
Autor:
Ana Martinez-Val, Dorte B. Bekker-Jensen, Sophia Steigerwald, Claire Koenig, Ole Østergaard, Adi Mehta, Trung Tran, Krzysztof Sikorski, Estefanía Torres-Vega, Ewa Kwasniewicz, Sólveig Hlín Brynjólfsdóttir, Lisa B. Frankel, Rasmus Kjøbsted, Nicolai Krogh, Alicia Lundby, Simon Bekker-Jensen, Fridtjof Lund-Johansen, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Protein activity regulated by phosphorylation can result in subcellular relocation. Here, the authors present a high throughput spatial phosphoproteomics approach to profile six subcellular compartments, providing insights into EGFR and stress signal
Externí odkaz:
https://doaj.org/article/e78dc7fb75d141e6a226079bfaa02397
Autor:
Giulia Franciosa, Jos G. A. Smits, Sonia Minuzzo, Ana Martinez-Val, Stefano Indraccolo, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and ident
Externí odkaz:
https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a
Autor:
Ana Martinez-Val, Cian J. Lynch, Isabel Calvo, Pilar Ximénez-Embún, Fernando Garcia, Eduardo Zarzuela, Manuel Serrano, Javier Munoz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Naïve pluripotency can be stabilized through different pharmacological approaches. Here, the authors profile temporal changes of protein phosphorylation, proteome and metabolome as mESCs transition to the naïve state in response to two pharmacologi
Externí odkaz:
https://doaj.org/article/6dc7983421e549f8afada656ff5c28a3
Autor:
Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Alexander Hogrebe, Ana Martinez-Val, Lynn Verbeke, Tejas Gandhi, Christian D. Kelstrup, Lukas Reiter, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Localizing phosphorylation sites by data-independent acquisition (DIA)-based proteomics is still challenging. Here, the authors develop algorithms for phosphosite localization and stoichiometry determination, and incorporate them into single-shot DIA
Externí odkaz:
https://doaj.org/article/448cb8a30d124c708cc21f898c76c600
Autor:
Cian J. Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 396-410 (2018)
Summary: The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report
Externí odkaz:
https://doaj.org/article/d244c9e2ea6c4ba0bee1530be287e16f
Autor:
Jesper V. Olsen, Jos G. A. Smits, Sonia Minuzzo, Giulia Franciosa, Ana Martinez-Val, Stefano Indraccolo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage an
Publikováno v:
Martinez-Val, A, Guzmán, U H & Olsen, J V 2022, ' Obtaining Complete Human Proteomes ', Annual Review of Genomics and Human Genetics, vol. 23, pp. 10.1-10.23 . https://doi.org/10.1146/annurev-genom-112921-024948
Proteins are the molecular effectors of the information encoded in the genome. Proteomics aims at understanding the molecular functions of proteins in their biological context. In contrast to transcriptomics and genomics, the study of proteomes provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a7b8e064b9b2c0e8fbe09a058ee2f5
https://curis.ku.dk/ws/files/358428665/annurev_genom_112921_024948.pdf
https://curis.ku.dk/ws/files/358428665/annurev_genom_112921_024948.pdf