Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Ana Martin-Villalba"'
Publikováno v:
eLife, Vol 12 (2024)
Fluorescence microscopy is a fundamental tool in the life sciences, but the availability of sophisticated equipment required to yield high-quality, quantitative data is a major bottleneck in data production in many laboratories worldwide. This proble
Externí odkaz:
https://doaj.org/article/507e24d6f2d343bbb863e900f0c2ea7d
Autor:
Damian Carvajal Ibañez, Maxim Skabkin, Jooa Hooli, Santiago Cerrizuela, Manuel Göpferich, Adrien Jolly, Katrin Volk, Marc Zumwinkel, Matilde Bertolini, Gianluca Figlia, Thomas Höfer, Guenter Kramer, Simon Anders, Aurelio A Teleman, Anna Marciniak‐Czochra, Ana Martin‐Villalba
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-18 (2023)
Abstract Stem cells show intrinsic interferon signalling, which protects them from viral infections at all ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to activate. Whether these functions are linked and at
Externí odkaz:
https://doaj.org/article/c039cae925bd4fe8acd4f4d3519e3e36
Autor:
Lukas P.M. Kremer, Santiago Cerrizuela, Sascha Dehler, Thomas Stiehl, Jonas Weinmann, Heike Abendroth, Susanne Kleber, Alexander Laure, Jihad El Andari, Simon Anders, Anna Marciniak-Czochra, Dirk Grimm, Ana Martin-Villalba
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 33-50 (2021)
The adult mammalian brain entails a reservoir of neural stem cells (NSCs) generating glial cells and neurons. However, NSCs become increasingly quiescent with age, which hampers their regenerative capacity. New means are therefore required to genetic
Externí odkaz:
https://doaj.org/article/20c78c1f028844548046b6a391c1e845
Autor:
Saskia Kutz, Ando C. Zehrer, Roman Svetlitckii, Gülce S. Gülcüler Balta, Lucrezia Galli, Susanne Kleber, Jakob Rentsch, Ana Martin-Villalba, Helge Ewers
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Ligand binding of membrane proteins triggers many important cellular signaling events by the lateral aggregation of ligand-bound and other membrane proteins in the plane of the plasma membrane. This local clustering can lead to the co-enrichment of m
Externí odkaz:
https://doaj.org/article/4e757870b0954ce690a565995c0a3375
Autor:
Robert Luck, Severino Urban, Andromachi Karakatsani, Eva Harde, Sivakumar Sambandan, LaShae Nicholson, Silke Haverkamp, Rebecca Mann, Ana Martin-Villalba, Erin Margaret Schuman, Amparo Acker-Palmer, Carmen Ruiz de Almodóvar
Publikováno v:
eLife, Vol 8 (2019)
Axon branching is crucial for proper formation of neuronal networks. Although originally identified as an angiogenic factor, VEGF also signals directly to neurons to regulate their development and function. Here we show that VEGF and its receptor VEG
Externí odkaz:
https://doaj.org/article/f35f5089b5394e5fb3f958611d90141c
Autor:
Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar, Ana Martin-Villalba
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1378-1393 (2017)
The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions
Externí odkaz:
https://doaj.org/article/f4c6c6f6c1234f02b796243e1b5ae530
Autor:
Moritz Drachsler, Susanne Kleber, Alvaro Mateos, Katrin Volk, Nadine Mohr, Si Chen, Branko Cirovic, Jochen Tüttenberg, Christian Gieffers, Jaromir Sykora, Christian Wirtz, Wolf Mueller, Michael Synowitz, Ana Martin-Villalba
Publikováno v:
Cell Death and Disease, Vol 11, Iss 7, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/7961588e50f24dfdafdb9d8e89f895fe
Autor:
Gülce S. Gülcüler Balta, Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka, Ana Martin-Villalba
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2295-2306.e6 (2019)
Summary: The death receptor CD95 is expressed in every cancer cell, thus providing a promising tool to target cancer. Activation of CD95 can, however, lead to apoptosis or proliferation. Yet the molecular determinants of CD95’s mode of action remai
Externí odkaz:
https://doaj.org/article/69bef3e3e9d64ded82caf8a5b412bc8b
Autor:
Sascha Dehler, Wilson Pak-Kin Lou, Liang Gao, Maxim Skabkin, Sabrina Dällenbach, Andreas Neumann, Ana Martin-Villalba
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
External stimuli such as injury, learning, or stress influence the production of neurons by neural stem cells (NSCs) in the adult mammalian brain. These external stimuli directly impact stem cell activity by influencing areas directly connected or in
Externí odkaz:
https://doaj.org/article/715b693505c647be8ba425322a88e954
Autor:
Wilson Pak-Kin Lou, Alvaro Mateos, Marta Koch, Stefan Klussman, Chao Yang, Na Lu, Sachin Kumar, Stefanie Limpert, Manuel Göpferich, Marlen Zschaetzsch, Christopher Sliwinski, Marc Kenzelmann, Matthias Seedorf, Carlos Maillo, Elena Senis, Dirk Grimm, Radhika Puttagunta, Raul Mendez, Kai Liu, Bassem A. Hassan, Ana Martin-Villalba
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2018)
Adult mammalian central nervous system (CNS) neurons are unable to regenerate following axonal injury, leading to permanent functional impairments. Yet, the reasons underlying this regeneration failure are not fully understood. Here, we studied the t
Externí odkaz:
https://doaj.org/article/57d79ae837a345689c77a63f8fc8df13