Semisynthesis of Dolabellane Diterpenes: Oxygenated Analogues with Increased Activity against Zika and Chikungunya Viruses

Autor: Freddy A. Ramos, Claudio Cesar Cirne-Santos, Jackson A. L. C. Resende, Ana Maria Viana Pinto, Caroline de Souza Barros, Maria Leonisa Sanchez Nunez, Izabel Christina Nunes de Palmer Paixão, Fabián Amaya García, Valéria Laneuville Teixeira, Leonardo Castellanos

Publikováno v: Journal of Natural Products. 84:1373-1384

Brown algae and soft corals represent the main marine sources of dolabellane diterpenes. The antiviral activity of dolabellanes has been studied for those isolated from algae, whereas dolabellanes isolated from soft corals have been barely studied. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccff962e75596957e0d93f6d92ff771
https://doi.org/10.1021/acs.jnatprod.1c00199

Global RNAseq of ocular cells reveals gene dysregulation in both asymptomatic and with Congenital Zika Syndrome infants exposed prenatally to Zika virus

Autor: Claudete Aparecida Araújo Cardoso, Raquel Hora Barbosa, Evandro Lucena, Thiago P. Silva, Livia Rosa-Fernandes, Amina Bedrat, Maria Luiza B. dos Santos, Ana Maria Viana Pinto, Giuseppe Palmisano, Rossana C. N. Melo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

In 2015, Brazil reported an outbreak identified as Zika virus (ZIKV) infection associated with congenital abnormalities. To date, a total of 86 countries and territories have described evidence of Zika infection and recently the appearance of the Afr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5fcee544325c9529ad8ef4a666ce93

Inhibition of Zika Virus Replication by Synthetic Bis-Naphthoquinones

Autor: Max Willian Lisboa Gomes, Ana Maria Viana Pinto, Roberta K. F. Marra, Rafaela dos Santos Pereira Gomes, Fernando de C. da Silva, Davis Fernandes Ferreira, Vitor F. Ferreira, Norman A. Ratcliffe, Izabel Christina Nunes de Palmer Paixão, Caroline de Souza Barros, Claudio Cesar Cirne-Santos, Daniel T. G. Gonzaga, Raissa M. A. Santos

Publikováno v: Journal of the Brazilian Chemical Society.

Zika virus (ZIKV) is a mosquito-borne pathogen which is a current global public health concern. There are currently no approved vaccines or antivirals against ZIKV infection. Taking into account that naphthoquinones have shown promising antiviral act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6ecfcd155a1cee8884814cdca197496
https://doi.org/10.21577/0103-5053.20190071

P5.05 Non-traditional strategies to approach topics related to sexually transmitted disease

Autor: Maria Clara Rodrigues Vieira, Robson dos Santos Souza Marinho, Ana Maria Viana Pinto

Publikováno v: Biomedical STI/HIV Prevention.

Introduction The traditional teaching strategies follow steps of activities and demonstrations generally directed by the teacher. This procedure may not provide students with valuable skills or even with knowledge that lasts much beyond the end of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6634fea8eecd14dcfbaaef9960f4eccd
https://doi.org/10.1136/sextrans-2017-053264.621

Caulerpin as a potential antiviral drug against herpes simplex virus type 1

Autor: Michele S. Ribeiro, Claudio Cesar Cirne-Santos, Viveca Giongo, Roberto Campos Villaça, Ana Maria Viana Pinto, Nathália Regina Porto Vieira Macedo, Izabel Christina Nunes de Palmer Paixão, Valéria Laneuville Teixeira, Wilton José Ferreira

Publikováno v: Revista Brasileira de Farmacognosia, Vol 22, Iss 4, Pp 861-867 (2012)
Revista Brasileira de Farmacognosia v.22 n.4 2012
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Revista Brasileira de Farmacognosia, Volume: 22, Issue: 4, Pages: 861-867, Published: 29 MAY 2012

About 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08ec428b07e6abec9dd5c31a8471afa
https://doi.org/10.1590/s0102-695x2012005000072