Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

Autor: Jeferson Machado Batista Sohn, Nathalie Carla Cardoso, Ana Maria Raymundi, Jos Prickaerts, Cristina Aparecida Jark Stern

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and BDNF expression. Depending on the brain region, PKA and pCREB mediate reconsolidat

Externí odkaz: https://doaj.org/article/2ee66150f7164e66aadfc86795d6c400

Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus

Autor: Yane Costa Chaves, Ana Maria Raymundi, Ana Paula Farias Waltrick, José Alexandre de Souza Crippa, Cristina Aparecida Jark Stern, Joice Maria da Cunha, Janaína Menezes Zanoveli

Publikováno v: Chaves, Y C, Raymundi, A M, Waltrick, A P F, Crippa, J A D S, Stern, C A J, Cunha, J M D & Zanoveli, J M 2023, ' Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus ', Acta Neuropsychiatrica . https://doi.org/10.1017/neu.2023.13

Objectives: In view of the neuroprotective characteristic of cannabidiol (CBD) and its beneficial action on aversive memory in non-diabetic animals, we aimed to investigate in animals with experimentally induced type-1 diabetes mellitus (T1DM) whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdac6d61c7a4b0c1199f6484aadc09f8
https://doi.org/10.1017/neu.2023.13

Effects of delta-9 tetrahydrocannabinol on fear memory labilization and reconsolidation: A putative role of GluN2B-NMDA receptor within the dorsal hippocampus

Autor: Francisco Guimaraes, Bruna Salemme, Cristina Aparecida Jark Stern, Ana Maria Raymundi, Nathalie Carla Cardoso, Jeferson Sohn

Publikováno v: Neuropharmacology. 225

Cannabis preparations could be an effective reconsolidation-based treatment for post-traumatic stress disorder. However, the effects of Δ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d06f381f03f7a5a51cf04716b0c2f2
https://pubmed.ncbi.nlm.nih.gov/36549374

A time‐dependent contribution of hippocampal CB 1 , CB 2 and PPARγ receptors to cannabidiol‐induced disruption of fear memory consolidation

Autor: Ana Maria Raymundi, Cristina A.J. Stern, Leandro J. Bertoglio, Aleksander Roberto Zampronio, Thiago R. da Silva, Francisco Silveira Guimarães

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background and purpose In preclinical studies, cannabidiol (CBD) mitigates fear memories by facilitating their extinction or interfering with their generalization and reconsolidation. The brain regions and mechanisms underlying these effects, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3caff277263d9a0dddd374d517d7877
https://doi.org/10.1111/bph.14895

Female but not male rats show biphasic effects of low doses of Δ9-tetrahydrocannabinol on anxiety: can cannabidiol interfere with these effects?

Autor: Bruna Wuilleumier Salemme, Cristina A.J. Stern, Ana Maria Raymundi, Jeferson Machado Batista Sohn, Beatriz Zanutto Salviato, Francisco Silveira Guimarães, Fabiano Soares Araújo, Leandro J. Bertoglio, Thiago R. da Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Δ9-tetrahydrocannabinol (THC) is the main phytocannabinoid present in the Cannabis sativa. It can produce dose-dependent anxiolytic or anxiogenic effects in males. THC effects on anxiety have scarcely been studied in females, despite their higher pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ea0e3e1e5734c97e73c62453aa2409