Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague–Dawley rats

Autor: Nuria Roglans, Miguel Baena, Gemma Sangüesa, Ana Magdalena Velázquez, Christian Griñán-Ferré, Mercè Pallàs, Rosa María Sánchez, Marta Alegret, Juan Carlos Laguna

Publikováno v: Food & Nutrition Research, Vol 65, Pp 1-15 (2021)

Background: Non-alcoholic fatty liver disease (NAFLD) has increased over the last decades and may evolve into hepatocellular carcinoma (HCC). As HCC is challenging to treat, knowledge on the modifiable risk factors for NAFLD/HCC (e.g. hyper caloric d

Externí odkaz: https://doaj.org/article/f1c37e51f156493784fda254eeeaf8d5

Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation

Autor: Ana Magdalena Velázquez, Núria Roglans, Roger Bentanachs, Maria Gené, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Marta Alegret

Publikováno v: Nutrients, Vol 12, Iss 11, p 3240 (2020)

Non-alcoholic fatty liver disease is a highly prevalent condition without specific pharmacological treatment, characterized in the initial stages by hepatic steatosis. It was suggested that lipid infiltration in the liver might be reduced by caffeine

Externí odkaz: https://doaj.org/article/81aeceb9683546b4ad6f32b07d9dba77

Bempedoic acid as a PPARα activator: New perspectives for hepatic steatosis treatment in a female rat experimental model

Autor: Roger, Bentanachs, Ana Magdalena, Velázquez, Rosa María, Sánchez, Marta, Alegret, Juan Carlos, Laguna, Núria, Roglans

Publikováno v: Clínica e Investigación en Arteriosclerosis (English Edition). 34:57-67

In its initial stages, nonalcoholic fatty liver disease presents hypertriglyceridemia and accumulation of lipids in the liver (hepatic steatosis). Bempedoic acid is an ATP:citrate lyase inhibitor that promotes a dual inhibition of the synthesis of ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a90d04f3757a22b938c632df5bb44f
https://doi.org/10.1016/j.artere.2022.03.001

El ácido bempedoico como activador PPARalpha: nuevas perspectivas para el tratamiento de la esteatosis hepática en un modelo experimental de rata hembra

Autor: Roger Bentanachs, Ana Magdalena Velázquez, Rosa María Sánchez, Marta Alegret, Juan Carlos Laguna, Núria Roglans

La enfermedad del hígado graso no alcohólico cursa, en sus fases iniciales, con hipertrigliceridemia y acúmulo de lípidos en el hígado (esteatosis hepática). El ácido bempedoico es un inhibidor de la ATP:citrato liasa que promueve una inhibici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1958f08c3ac0f9a8780aef4c4faaf99b
http://hdl.handle.net/2445/183947

mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars

Autor: Ana Magdalena Velázquez, Gemma Sangüesa, Núria Roglans, Marta Alegret, Juan C. Laguna, Miguel Baena

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1117 (2019)
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

One of the most important threats to global human health is the increasing incidences of metabolic pathologies (including obesity, type 2 diabetes and non-alcoholic fatty liver disease), which is paralleled by increasing consumptions of hypercaloric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3686d67d46483fe3ae622a9b775c2c48
https://pubmed.ncbi.nlm.nih.gov/30841536